Synthesis and Anti-Inflammatory Activity of 4(3H)- Quinazolinone and Its 2-Methyl and 2-Phenyl-4 (3H)- Quinazolinone Derivatives
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 4
Abstract
Some 4(3H)-quinazolinone and its derivatives with potential anti-inflammatory properties were synthesized from the reaction of anthranilamide and the proper triethyl orthoacetate, triethyl orthoformate and triethyl orthobenzoate. All the compounds synthesized were unequivocally confirmed by means of infrared, Nuclear Magnetic Resonance (1H and 13C), Gas chromatography Mass Spectrophotometer, and elemental analysis. The quinazolinones were evaluated pharmacologically for their in vivoanti-inflammatory activities by carrageenan-induced rat paw oedema. All the investigated compounds exhibited significant anti-inflammatory activity in the range of 81-96% in comparison to control.
Authors and Affiliations
Osarumwense P. O, Edema M. O. , Usifoh O.
Keywords
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