Synthesis and Anti-Inflammatory Activity of Novel Quinazoline Derivatives based on Ethyl-4-Oxo-3H-Quinazoline-2- Carboxylatescaffold: Docking Studies
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 5
Abstract
Novel derivatives of quinazoline linked oxazines throughamide linkage have been synthesized and evaluated for inhibition against inflammation. The synthesized compounds were characterized by 1H NMR, 13C NMR FTIR and mass spectral data and tested for in-vivo anti-inflammatory activity using Carrageenan induced paw inflammatory model as well as docking studies were performed in order to elucidate structural insights for the anti-inflammatory activity. The investigation of anti-inflammatory activity screening and Docking results showed that the compound QOA-b exhibited good anti-inflammatory activity among all the synthesized compounds.
Authors and Affiliations
Jagadeesh Babu Vadlakonda, M. Srinivasa Murthy2, M. Saritha3
Keywords
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- EP ID EP386657
- DOI 10.9790/3008-11050496101
- Views 61
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