SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NEW SUBSTITUTED AZETIDINE DERIVATIVES
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
Four-membered nitrogen heterocycles such as β-lactams and azetidines are useful substrates in organic chemistry for the design and preparation of biologically active compounds. New series of 4(3-Chloro-(Substituted-Phenyl)-4-oxoazetidine1-yl)1-phenylthiosemicaebazide derivative were synthesized by the reaction of Schiff base with 2-Chloro acetyl chloride. Synthesized compounds were evaluated for their Anti- bacterial activity against Gram positive bacteria (Bacillus Subtilis) and gram negative bacteria (Klebsiella pneumonia). In this synthesis 6 derivatives are used named as NM1, NM2, NM3, NM4, NM5 and NM6.Synthesized compounds show significant activity against bacteria strains on agar plate. Their structures were established on the basis of elemental analysis, IR and NMR spectral data. The different substituted azetidine derivatives were synthesized followed by cyclization reaction. The newly synthesized azetidine derivatives were evaluated for their antimicrobial activity. The synthesized compounds NM1 showed effective antimicrobial activity. This clearly indicates that new azetidine derivatives can be effectively synthesized by method mentioned in this study.
Authors and Affiliations
Rajni Shah
Keywords
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