Synthesis and Antimicrobial Evaluation of Pegylated Thiazoles
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 12
Abstract
Drug–polymer conjugation is a modest and competent approach to synthesizing new, effective, and potent antimicrobial agents to counter the problem of microbial resistance. In the present study, a PEGylated thiazoles were synthesized by using the PEGylation process. A series of PEGylated amino thiazoles were evaluated for antibacterial activity against the gram negative , gram positive bacterial strains i.e.,Escherichia coli & Staphylococcus aureus respectively, using cup plate method. Among all PEGylated thiazoles, many derivatives exhibited significant microbial activity against bacterial strains. The newly synthesized compounds were characterized by elemental analysis, IR and 1HNMR, 13CMR and Mass spectral data.
Authors and Affiliations
Sonali S. Rahate, Anjali M. Rahatgaonkar
Keywords
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- EP ID EP431724
- DOI 10.9790/5736-1112016672.
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