SYNTHESIS AND ASSESSMENT OF HEPATOPROTECITVE ACTIVITY OF SOME NEW 2-ARYL TETRAHYDROQUINOLINE AND SPIROOXYINDOLYL TETRAHYDROQUINOLINE DERIVATIVES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 2
Abstract
Objective: To evaluate the hepatoprotecitve potential of some newly synthesized tetrahydroquinoline derivatives against carbon tetrachloride induced hepatic damage in wister rats.Methods: A series of 2-aryl, 4-N vinyl pyrrolido/caprolacto and spirooxy indolyl tetrahydroquinolines were synthesized by imino Diels-Alder reaction using Antimony (III) sulfate as catalyst. The titled compounds were characterized by IR, 1HNMR spectroscopy and screened for hepatoprotecitve activity. Hepatopotoxicity was induced in male Wister rats by intrperitoneal injection of CCl4. Wister rats weighing 150-200g were randomly assigned in to various groups of six animals each. Group I – Normal control received only 1% Tween in distilled water, Group II – Served as negative control received CCl4 in liquid paraffin 1 ml/kg p. o. at every 72 h for 10 days. Group III – X were intoxicated with CCl4 1 ml/kg p. o. before the administration of Silymarin 100 mg/kg p. o. and suspension of synthetic derivatives in polyethylene glycol-400 at the dose of 25 mg/kg p. o. for 10 days. Different hepatic biochemical parameters viz. SGOT, SGPT, SALP, Total and direct bilirubin were evaluated before and after treatment to investigate the hepatoprotecitve activity.Results: It was observed that in CCl4 intoxicated group; total and direct bilirubin, SGOT, SGPT, SALP levels were significantly increased as compared to control group. Administration of synthesized tetrahydroquinoline derivatives at the dose of 25 mg/kg p. o. reduced these pathological damages caused by CCl4 intoxication compared to normal and Silymarin treated groups.Conclusion: The present study revealed that synthesized tetrahydroquinoline derivatives, showed hepatoprotecitve potential against CCl4 induced hepatotoxicity in wister rats, thus offering a novel synthetic formulation as a hepatoprotecitve drug.Â
Authors and Affiliations
Mahesh Anand Goudar, Jayadevappa H. , Mahadevan K. M, Shastry R. A. , Habbu P. V. , Sayeswara H. A
Keywords
Related Articles
- EP ID EP579084
- DOI -
- Views 80
- Downloads 0
LIQUISOLID COMPACTS: AN INNOVATIVE APPROACH FOR DISSOLUTION ENHANCEMENT
The challenge faced by the majority of the pharmaceutical products is the poor solubility of the drug candidates which leads to low bioavailability. Liquisolid compact is one of the emerging techniques that enhances the...
ISOLATION AND CHARACTERIZATION OF SECONDARY METABOLITES FROM PITHECELLOBIUM DULCE BENTH FRUIT PEEL
Objective: The present study describes the isolation and characterization of valuable secondary metabolites from the fruit peel of Pithecellobium dulce. Methods: Solvent extraction of the plant material using methanol fo...
ETHANOL ROOT EXTRACT OF THE AFRICAN APHRODISIAC, MONDIA WHITIE (PERIPLOCACEAE), POSSESES ESTROGENIC ACTIVITY
Objective: To determine the effects of ethanol extract of the dried root Mondia whitie (mondia) on female reproductive system using the chick uterotrophic assay and the rodent estrous cycle studies.Methods: Phytochemical...
FACTORS AFFECTING POSTPARTUM DEPRESSION AMONG WOMEN OF THE UAE AND OMAN
Objective: Is to evaluate factors related to the development of postpartum depression among an United Arab Emirates and Omani societies.Methods: The study was prospective, observational, and descriptive using a self-repo...
SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTIMICROBIAL EVALUATION OF SOME NEW AMIDES OF THIOMORPHOLINE CARBOXYLATE
Objective: Synthesis and antimicrobial evaluation of some new amides of Thiomorpholine caboxylate.Methods: A series of new amides of Thiomorpholine caboxylate were synthesized by reacting 4-tert-butyl 2-methyl thiomorpho...