SYNTHESIS AND BIOLOGICAL ACTIVITY OF DERIVATIVES (2-METHYL (PHENYL) -6-R-QUINOLIN-4-YL-SULPHANYL) CARBOXYLIC ACIDS
Journal Title: Science Review - Year 2017, Vol 7, Issue 7
Abstract
Selection of potential bioactive molecules (2-methyl (phenyl) -6-R-quinolin-4-yl-sulfanyl) carboxylic acids and their derivatives with virtual screening (PASS-prognosis) and QSAR analysis was carried out. The most promising compounds were synthesized and their toxic effects were studied. They found themselves as little or moderately toxic biologically active substances. The conducted experiments indicate the expediency of in-depth study of derivatives (2-methyl (phenyl) -6-R-quinolin-4-yl-sulfanyl) carboxylic acids as potential bioregulators.
Authors and Affiliations
O. A. Brazhko, M. P. Zavgorodniy, A. V. Lagron, M. M. Kornet, I. V. Dobrodub
Keywords
Related Articles
- EP ID EP409109
- DOI -
- Views 119
- Downloads 0
О ЖАНРОВОМ ПОДХОДЕ В ИЗУЧЕНИИ МУЗЫКАЛЬНОЙ ЛИТЕРАТУРЫ В СПЕЦИАЛЬНЫХ МУЗЫКАЛЬНЫХ ШКОЛАХ
Musical literature is the most important discipline for the formation of young musicians. The genre approach is based on the study of this subject in grades 5-7 in the Republican Specialized Musical Academic Lyceum named...
СИСТЕМА ДИДАКТИЧЕСКОГО ТЕСТИРОВАНИЯ РЕЗУЛЬТАТОВ ОБУЧЕНИЯ В ВУЗЕ
The article describes the elements of the system of quality control of the development of educational programs based on the principles of didactic diagnosis of learning outcomes, allowing you to create a model for measur...
ВИКОРИСТАННЯ РІЗНИХ ФОРМ ТА МЕТОДІВ НАВЧАННЯ СТУДЕНТІВ МЕДИЧНОГО УНІВЕРСИТЕТУ НА КАФЕДРІ БІООРГАНІЧНОЇ I БІОЛОГІЧНОЇ ХІМІЇ ТА КЛІНІЧНОЇ БІОХІМІЇ
The article presents ways of organizing the educational process using different forms and methods of teaching medical students with the introduction of the latest innovative pedagogical methods and information and commun...
ПОЛИТИЧЕСКИЙ КРИЗИС В СОВРЕМЕННОЙ ТУРЦИИ
The events, occurring in neighboring Turkey in 2015, attracted the attention of the whole world. Naturally, these events have become, first of all, the focus of interest for Georgia. As the situation in Turkey has always...
PROFESSIONALLY IMPORTANT PERSONAL QUALITIES OF THE TEACHER OF THE HIGHER EDUCATION IN THE STRUCTURE OF PROFESSIONAL PEDAGOGICAL COMPETENCIES
Relevance. The introduction of first-generation standards ensured the availability of general requirements for graduates, on the basis of which universities developed educational and methodological documentation. The pu...