Synthesis and Biological Evaluation Of Some 2-Substituted Derivatives Of Benzimidazoles
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 4
Abstract
A large variety of 2-substituted benzimidazoles have been found to possess anti-inflammatory, antispasmodic, a ntihistaminic, a ntimicrobial, anticancer, c ycloxygenase inhibitor, and HIV-1 reverse transcriptase inhibitor activi ties. 2-alkyl benzimidazole and 2-aryl benzimidazoles were synthesized with different acids namely a cetic acid, o-c hlorobenzoic ac id, b enzoic ac id a nd cinnamic a cid. These were f urther treated with tosyl c hloride a nd benzoyl c hloride t o get Nsubstituted be nzimidazole de rivatives. These N-substituted be nzimidazoles wer e tested for antimicrobial ac tivity a gainst Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Some o f th e products exhibited interesting ac tivity wi th known s tandard drug at same concentration. The study was aimed to develop some benzimidazoles with antimicrobial activity.
Authors and Affiliations
S. K. Gupta , M. P. Khinchi , S S Pancholi , M K Gupta , Dilip Agrawal
Keywords
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