SYNTHESIS AND CHARACTERIZATION OF 1, 3, 4-OXADIAZOLE AND 1,3,4- THIADIAZOLE
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 3
Abstract
There are vast numbers of pharmacologically active heterocyclic compounds in regular clinical use. The presence of heterocyclic structures in diverse types of compounds is strongly indicative of the profound effects such structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic drugs. The 1, 3, 4-oxadiazole and 1,3,4- thiadiazole nucleus has emerged as one of the potential pharmacophore responsible for diverse pharmacological properties. Literature is flooded with reports of a variety of biological activities of 2, 5-Disubstituted-1,3,4- oxadiazoles and 1,3,4- thiadiazole. The search for better anticonvulsant drug and the importance of 2,5- disubstituted 1,3,4-oxadiazoles and 1,3,4- thiadiazole as anticonvulsant pharmacophores, prompted us to design, synthesize and evaluate a series of differently substituted 1,3,4-oxadiazoles and 1,3,4- thiadiazole for their potential anticonvulsant activity by autodock software.
Authors and Affiliations
Ramanji Naik
Keywords
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