Formulation and characterization of Methotrexate loaded sodium alginate chitosan Nanoparticles
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 6
Abstract
The aim of the present work was to formulate nanoparticles for Methotrexate drug. Methotrexate is an anticancer, disease modifying anti rheumatic drug, and BCS Class – III drug having high solubility and low permeability. Nanoparticles were prepared by ionotropic pregelation method using Box Behnen Formula. The concentration of chitosan (X1),concentration of sodium alginate (X2) and concentration of Methotrexate (X3) were chosen as independent variables while particle size, drug entrapment efficiency and percentage drug release at 36th hour, was taken as dependent variables. The dissolution profile of selected formulations was fitted to zero order, first order, Higuchi and Korsemayer Peppas models to ascertain the kinetic modeling of drug release. The prepared formulations were further evaluated for characterization like surface morphology, particle size distribution, zetapotential and drug excipient interaction study by Fourier Transformer Infra Red Spectroscopy, Differential Scanning Calorimetry and X-ray Diffraction. All independent variables were found to significantly influence the particle size, entrapment efficiency and percentage of drug release. The in- vitro drug release profile showed that the suitability of sodium alginate-chitosan loaded nanoparticles in controlled release of methotrexate for prolonged time.
Authors and Affiliations
S. Daisy Chella Kumari, C. B. Tharani, N. Narayanan, C. Senthil Kumar
Keywords
Related Articles
- EP ID EP33145
- DOI -
- Views 350
- Downloads 0
The neohydrodynamic theory of dentinal hypersensitivity
The neohydrodynamic theory of dentinal hypersensitivity is to reveal the real mechanism behind the dentinal hypersensitivity. The hydrodynamic theory proposed by Branstrom will support only under pathological condition...
Application of Nanotechnology in Commercial field
The materials which are processing to a grain size of a billionth of a meter are called nanomaterials or nanoparticles. The naturally occurring or the incidental byproducts of combustion processes are usually physicall...
A simple validated UV spectrophotometric method for quantitative analysis of Levetiracetam in pharmaceutical dosage form
In the present study simple, precise, accurate, economical and reliable UV spectrophotometric method has been developed for the estimation of Levetiracetam in tablet dosage form. The drug shows maximum absorption (maxi...
SCREENING OF BIOACTIVE ACTINOMYCETES FROM SUGARCANE SOILS
Actinomycetes and Streptomyces are once considered to be microbiological curiosities of no great economic importance, but have become the subjects of intensive searches for source of new biologically active compounds....
Phytochemical and anti diarrhoeal activity of Hippocratea africana roots
Diarrhoea is a condition that involves frequent passing of loose or watery stools. According to the Who, approximately 3.5million deaths each year are attributable to diarrhoea. Medicinal plants have been used as tradi...