Formulation and characterization of Methotrexate loaded sodium alginate chitosan Nanoparticles
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 6
Abstract
The aim of the present work was to formulate nanoparticles for Methotrexate drug. Methotrexate is an anticancer, disease modifying anti rheumatic drug, and BCS Class – III drug having high solubility and low permeability. Nanoparticles were prepared by ionotropic pregelation method using Box Behnen Formula. The concentration of chitosan (X1),concentration of sodium alginate (X2) and concentration of Methotrexate (X3) were chosen as independent variables while particle size, drug entrapment efficiency and percentage drug release at 36th hour, was taken as dependent variables. The dissolution profile of selected formulations was fitted to zero order, first order, Higuchi and Korsemayer Peppas models to ascertain the kinetic modeling of drug release. The prepared formulations were further evaluated for characterization like surface morphology, particle size distribution, zetapotential and drug excipient interaction study by Fourier Transformer Infra Red Spectroscopy, Differential Scanning Calorimetry and X-ray Diffraction. All independent variables were found to significantly influence the particle size, entrapment efficiency and percentage of drug release. The in- vitro drug release profile showed that the suitability of sodium alginate-chitosan loaded nanoparticles in controlled release of methotrexate for prolonged time.
Authors and Affiliations
S. Daisy Chella Kumari, C. B. Tharani, N. Narayanan, C. Senthil Kumar
Keywords
Related Articles
- EP ID EP33145
- DOI -
- Views 352
- Downloads 0
Need of drug discovery to cure Ebola fever
Hygienic environment is an important requisite for maintenance of good health. The term ‘hygiene’ includes not only the material environment but also personal hygiene. The importance of personal hygiene should continua...
Analytical method development and validation for the simultaneous estimation of Levamisole and Mebendazole in bulk & tablet formulation by RP-HPLC method
A fast, robust and accurate RP-HPLC method was developed and validated for simultaneous determination of Levamisole and Mebendazole in tablets. The mobile phase was mixture of aqueous phosphate buffer with pH 5.2: Meth...
Formulation and evaluation of Lornoxicam transferosomes as carriers for effective transdermal drug delivery
The aim of this research activity is to formulate Soyalecithin based Transfersomal Nanoparticles for percutaneous administration of Lornoxicam for better management against pain, especially inflammatory diseases of joi...
The latest statistical report of the global synthetic drugs
As stated by the world Drug Report 2017 pellucidly exhibit, there is to large extent work to be done to tackle the many harms inflicted by drugs, to health, peace and security and development in every region of the wor...
Simultaneous Estimation of Rosuvastatin Calcium and Ezetamibe in Tablet Dosage form by RP-HPLC
A simple reverse phase high performance liquid chromatography(RP-HPLC)method has been developed and validated for simultaneous estimation of Rosuvastatin calcium(ROS) and Ezetamibe(EZE)in pharmaceutical dosage form. Th...