Formulation and characterization of Methotrexate loaded sodium alginate chitosan Nanoparticles

Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 6

Abstract

The aim of the present work was to formulate nanoparticles for Methotrexate drug. Methotrexate is an anticancer, disease modifying anti rheumatic drug, and BCS Class – III drug having high solubility and low permeability. Nanoparticles were prepared by ionotropic pregelation method using Box Behnen Formula. The concentration of chitosan (X1),concentration of sodium alginate (X2) and concentration of Methotrexate (X3) were chosen as independent variables while particle size, drug entrapment efficiency and percentage drug release at 36th hour, was taken as dependent variables. The dissolution profile of selected formulations was fitted to zero order, first order, Higuchi and Korsemayer Peppas models to ascertain the kinetic modeling of drug release. The prepared formulations were further evaluated for characterization like surface morphology, particle size distribution, zetapotential and drug excipient interaction study by Fourier Transformer Infra Red Spectroscopy, Differential Scanning Calorimetry and X-ray Diffraction. All independent variables were found to significantly influence the particle size, entrapment efficiency and percentage of drug release. The in- vitro drug release profile showed that the suitability of sodium alginate-chitosan loaded nanoparticles in controlled release of methotrexate for prolonged time.

Authors and Affiliations

S. Daisy Chella Kumari, C. B. Tharani, N. Narayanan, C. Senthil Kumar

Keywords

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  • EP ID EP33145
  • DOI -
  • Views 352
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How To Cite

S. Daisy Chella Kumari, C. B. Tharani, N. Narayanan, C. Senthil Kumar (2013). Formulation and characterization of Methotrexate loaded sodium alginate chitosan Nanoparticles. Indian Journal of Research in Pharmacy and Biotechnology, 1(6), -. https://europub.co.uk/articles/-A-33145