Synthesis and Comparative Spectroscopic Characterization of N-Protected Amino Esters, Bioactive
Journal Title: PhytoChem & BioSub Journal - Year 2018, Vol 12, Issue 2
Abstract
Methyl (pyridin-2-ylmethyl) phenylalaninate and methyl benzylphenylalaninate were prepared by reaction of the phenylalanine methyl ester with bromobenzyl bromide and bromomethylpyridine derivatives The carbon-nitrogen bonds are ubiquitous in natural products and organic material, that is why we are interested in the synthesis of amino acid derivatives which require prior protection of the acid function by esterification and that of the amine function by alkylation. The amino acid materials thus prepared, once protected can be used later to incorporate heterocycles within them, and in the α position, capable of imparting interesting biological properties.
Authors and Affiliations
FAR H, BENAISSA T, DAOUDI S
Keywords
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