SYNTHESIS, CHARACTERISATION AND ANTICANCER ACTIVITY OF SCHIFF BASE DERIVATIVES OF 5-(2-PHENOXYPYRIDIN-3-YL)-1, 3, 4-THIADIAZOL-2-AMINE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 12
Abstract
Schiff Bases of 5-(2-phenoxypyridin-3-yl)-1, 3, 4-thiadiazol-2-aminederivatives 6(a-h) have been synthesized with different aromatic aldehyde and tested for in vitro anticancer activity; the 1, 3, 4-thiadiazole derivatives were prepared by the reaction ofthiosemicarbazide, phosphorousoxychloride and aromatic acids. The synthesized final Schiff base compounds were purified by column-chromatography and the structures of the titled Schiff bases were elucidated by IR, 1H NMR and LCMS spectral measurements. Three different cell lines namely Hela, Hep-G2 and MCF7 are used for the present study. The compounds tested were, in most of cases shows cytotoxic effect but, only one compound showed good activity on breast carcinoma cell line having IC50 = 2.28 μg/ mL.
Authors and Affiliations
Vinayak Adimule , Sudha Medapa , Prakash Rao , Lalita Kumar
Keywords
Related Articles
- EP ID EP93841
- DOI 10.7897/2230-8407.041214
- Views 114
- Downloads 0
HEPATOPROTECTIVE EFFECT OF AQUEOUS AND N-HEXANE EXTRACT OF NIGELLA SATIVA IN PARACETAMOL (ACETAMINOPHEN) INDUCED LIVER DISEASES OF RATS: A HISTOPATHOLOGICAL EVALUATION
Acute over dose of paracetamol (acetaminophen) causes serious hepatic necrosis. So, this study was conducted to observe the hepatoprotective activity of aqueous and n-hexane extract of Nigella sativa in paracetamol induc...
PILOT STUDY FOR DETERMINATION OF BLOOD LEAD LEVELS IN PRIMARY SCHOOL CHILDREN
Exposure to lead can damage the nervous, hematopoietic, and renal systems and is particularly harmful to the developing nervous systems of fetuses and children. Most children who have elevated blood lead levels do not ha...
PRODUCTION AND PARTIAL CHARACTERIZATION OF CITRIC ACID BY LOCAL ISOLATE OF ASPERGILLUS NIGER USING SORGHUM
In the present study, the citric acid producing organisms were isolated from soil sample using serial dilution technique and the isolate were identified on the basis of their microscopic and morphological characteristics...
DENDRITIC ARCHITECTURE: A NEW TOOL FOR DEVELOPMENT OF NOVEL DRUG DELIVERY SYSTEMS
Dendrimers are composed of a multifunctional core molecule attached to polymer branches. Drugs can be inserted between the branches and held until ‘interactions’ release it. Dendrimers are a new class of three-dimensiona...
GC-MS ANALYSIS OF ETHANOLIC EXTRACT OF POLYPODIUM DECUMANUM
A gas chromatography-mass spectrometry was carried out on a Agilent GC-MS 5975 under electron impact ionization (70 eV). The chromatographic column for the analysis was done by the HP5MS capillary column (30 m x 0.25 mm...