Synthesis, characterization and antibacterial activity of various substituted oxadiazolylpyrazolinyl/isoxazolinylcoumarin derivatives
Journal Title: International Journal of Pharma Sciences and Research - Year 2010, Vol 1, Issue 1
Abstract
A series of 7-un/substituted-2-spiro-[5-((1-acetyl-5-(substitutedphenyl)amino)-3-(1-acetyl-5-(substitutedphenyl)) pyazolin-3-yl)-1,3,4-oxadiazol-2-yl]coumarins (4a-4h) and 7-un/substituted-2-spiro-2-[(-5-(substitutedphenyl)amino-4-(5-(substitutedphenyl))pyazolin-3-yl)-1,3,4-oxadiazol-2-yl]coumarins (5a-5h) by the reaction of 7-un/substituted-2-spiro-(3-substitutedarylidinyl chalconyl)-5-(substitutedarylidinylaminochalconyl)-oxadiazol-2-yl)coumarins (3a-3h) with hydrazine hydrate and hydroxyl amine respectively. All the newly synthesized compounds were screened for their antibacterial activity against K. pneumoniae, S. aureus, E. coli and B. sublitis and were compared with the standard drug ciprofloxacin. The most potent antibacterial compound of this series was 4g. Structure of all the compounds were established by the elemental (C, H, N) and spectral (IR, 1H NMR and mass) analysis.
Authors and Affiliations
Hemlata Kaur , Sunil Kumar , Indu Singh , Ashok Kumar
Keywords
Related Articles
- EP ID EP113269
- DOI -
- Views 135
- Downloads 0
SPECTROPHOTHOMETRIC DETERMINATION OF GATIFLOXACIN THROUGH COMPLEXATION WITH SURFACTANT
A simple, quick and sensitive U.V spectrometric method has been developed for the quantitative estimation of Gatifloxacin in bulk and pharmaceutical formulation. The method was based on the complexation with neutral surf...
SIMPLE COLORIMETRIC ASSAY FOR MICROGRAM DETERMINATION OF BROMHEXINE HYDROCHLORIDE WITH MBTH AND 2, 2’ BIPYRIDYL
The present work describes two new spectrophotometric methods for the determination of bromhexine hydrochloride in bulk and formulations. Method A is based on the reduction of Fe3+ into Fe2+ by the drug followed by the c...
Hepatoprotective Activity of Leucas lavandulaefolia Against Carbon tetrachloride-Induced Hepatic Damage In Rats
The aerial parts of [i]Leucas lavandulaefolia[/i] Rees, family Labiatae was tested for hepatoprotective activity against CCl4 in rats. The ethyl acetate extract of [i]Leucas lavandulaefolia[/i] has shown significant act...
Homology Modelling and Insilico Analysis of Hemagglutinin Protein from H1n1 Influenza A Virus
World wide spread of H1NI Influenza A Virus has raised concerns. Modelling of Hemagglutinin protein of Influenza A virus (A/Sakai/1/2009(H1N1)) Hemagglutinin (HA) protein was done using Modeller 9V2. Modelled structure w...
Method Development and Validation for The Simultaneous Estimation of Ofloxacin and Ornidazole in Tablet Dosage Form by Rp-Hplc
A simple reverse phase liquid chromatographic method has been developed and subsequently validated for simultaneous determination of Ofloxacin and Ornidazole in combination. The separation was carried out using a mobile...