Synthesis, characterization and antibacterial activity of various substituted oxadiazolylpyrazolinyl/isoxazolinylcoumarin derivatives
Journal Title: International Journal of Pharma Sciences and Research - Year 2010, Vol 1, Issue 1
Abstract
A series of 7-un/substituted-2-spiro-[5-((1-acetyl-5-(substitutedphenyl)amino)-3-(1-acetyl-5-(substitutedphenyl)) pyazolin-3-yl)-1,3,4-oxadiazol-2-yl]coumarins (4a-4h) and 7-un/substituted-2-spiro-2-[(-5-(substitutedphenyl)amino-4-(5-(substitutedphenyl))pyazolin-3-yl)-1,3,4-oxadiazol-2-yl]coumarins (5a-5h) by the reaction of 7-un/substituted-2-spiro-(3-substitutedarylidinyl chalconyl)-5-(substitutedarylidinylaminochalconyl)-oxadiazol-2-yl)coumarins (3a-3h) with hydrazine hydrate and hydroxyl amine respectively. All the newly synthesized compounds were screened for their antibacterial activity against K. pneumoniae, S. aureus, E. coli and B. sublitis and were compared with the standard drug ciprofloxacin. The most potent antibacterial compound of this series was 4g. Structure of all the compounds were established by the elemental (C, H, N) and spectral (IR, 1H NMR and mass) analysis.
Authors and Affiliations
Hemlata Kaur , Sunil Kumar , Indu Singh , Ashok Kumar
Keywords
Related Articles
- EP ID EP113269
- DOI -
- Views 142
- Downloads 0
Synthesis, characterization and antibacterial activity of various substituted oxadiazolylpyrazolinyl/isoxazolinylcoumarin derivatives
A series of 7-un/substituted-2-spiro-[5-((1-acetyl-5-(substitutedphenyl)amino)-3-(1-acetyl-5-(substitutedphenyl)) pyazolin-3-yl)-1,3,4-oxadiazol-2-yl]coumarins (4a-4h) and 7-un/substituted-2-spiro-2-[(-5-(substitutedphen...
SIMPLE COLORIMETRIC ASSAY FOR MICROGRAM DETERMINATION OF BROMHEXINE HYDROCHLORIDE WITH MBTH AND 2, 2’ BIPYRIDYL
The present work describes two new spectrophotometric methods for the determination of bromhexine hydrochloride in bulk and formulations. Method A is based on the reduction of Fe3+ into Fe2+ by the drug followed by the c...
Isolation and characterization of stigmast-5-en-3β-ol (β-sitosterol) from the leaves of Hygrophila spinosa T. Anders
Purpose: [i]Hygrophila spinosa[/i] T. Anders (Acanthaceae) commonly known as ‘Talmakhana’ in Hindi contains a number of phytoconstituents viz. alkaloids, phytosterols, glycosides, amino acids, proteins, phenolic acids, e...
Does screening of pregnant women prevent mother to child transmission of HIV?A study in nsukka urban area of Enugu State, Nigeria.
[b]Background:[/b] One of our best opportunities for progress against AIDS lies in preventing mothers from passing on the HIV virus to their children. Worldwide, close to 2,000 babies are infected with HIV every day, dur...
Aloe vera: Plant of Immortality
The Egyptians called Aloe the “Plant of Immortality” because it can live and even bloom without soil. Aloe has been used medicinally since at least the first century C.E. and continues to be used extensively worldwide....