Synthesis, Characterization and In Vitro Antioxidant Activities of New Benzimidazole Ruthenium- (II) Complexes
Journal Title: Cumhuriyet Science journal - Year 2017, Vol 38, Issue 4
Abstract
In this study; it was first intended to synthesize 1-substituted benzimidazole ligands containing a nitrogen-bound bulky or functional group and then preparing Ru- (II) -N coordinated metal complexes of these ligands. At last stage of study it has been investigated that the antioxidant activities of synthesized metal-complexes. Inert atmosphere-vacuum system has been used for the synthesis of all complexes. Their structure were characterized by spectroscopic techniques. The in vitro antioxidant activities of metal complexes were investigated based on the scavenging of hydroxyl, superoxide and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. In addition, total antioxidant activity of each metal-complex was also determined. It was determined that total antioxidant activities of metal-complexes increased by the order of 3, 4 and 2. Because of decreasing IC50 values indicates that increasing antioxidant activity, DPPH radical scavenging activity of complex 2, which has lower IC50 value, was greater than complex 4. IC50 values have not seen for complex 3 for DPPH. It was observed that hydroxyl radical scavenging activities of complexes increased 4, 3 and 2, while superoxide radical scavenging activities of complexes increased by the order of 3, 2 and 4, respectively. As a result; newly synthesized Ru (II) -azole complexes have been found to have significant antioxidant activity against DPPH, hydroxyl and superoxide radicals.
Authors and Affiliations
Serap ŞAHİN BÖLÜKBAŞI, Neslihan ŞAHİN
Keywords
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- EP ID EP488449
- DOI 10.17776/csj.349326
- Views 38
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