Synthesis, formulation and evaluation of Chalcone as potent antimicrobial agent
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 3
Abstract
In a wide search program towards new and efficient antimicrobial agent chalcone has been synthesized by condensing benzaldehyde derivatives with acetophenone derivatives in dilute ethanolic sodium hydroxide solution at room temperature according to Claisen Schmidt condensation. Then synthesized compound formulated and evaluated as enteric coated tablets to reduce the gastrointestinal tract side effects. Enteric coat was employed by using different polymers such as HPMC-55, Eudragit and Ethyl cellulose in different ratios. Formulation exhibited optimum dissolution, disintegration, hardness and friability properties. The antimicrobial activity of the novel products were evaluated by filter paper disc diffusion method. This study concluded that enteric coated tablets of chalcone can be prepared by using combination of polymers with optimum quality control parameters which ultimately reduces the GI tract side effects and retained its potency as antimicrobial agents.
Authors and Affiliations
Biresh Kumar Sarkar, Manish Devgan, Himmat Singh
Keywords
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