Synthesization of o-amino Benzonic Acid Modified β-cyclodextrin and Palladium Catalyzed Heck Coupling Reaction in Aqueous Media
Journal Title: 河南科技大学学报（自然科学版） - Year 2019, Vol 40, Issue 3
Abstract
Taking o-amino benzonic acid andβ-CD as raw materials, mono- (6-o-amino benzonic acid-6-deoxy) -β-CD was synthesized and characterized by1H NMR and13C NMR.Heck coupling reaction was proceeded with high efficiency in aqueous media by using mono- (6-o-amino benzonic acid-6-deoxy) -β-CD as the ligand and palladium acetate as the palladium source.The effects of catalyst loadings, bases, reaction temperature and reaction time on Heck coupling reaction were explored, and the scope of the substrates was analyzed.The results show iodobenzene can almost be converted totally by utilizing iodobenzene and styrene as substrates, K2CO3as the base, with 0.20%of the catalyst loading, at 130℃for 10 h.Under the optimized reaction conditions, the coupling yields of the substrates can be above 80%and the yields are influenced by the steric hinderance and electronic effect.
Authors and Affiliations
Xinglong ZHOU, Xuming GUO, Huangyi WU, Fangfang JIAN
Keywords
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- EP ID EP469113
- DOI 10.15926/j.cnki.issn1672-6871.2019.03.017
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