The Anti-Inflammatory and Analgesic Effects Of the Aqueous Leaves Extract of Carica Papaya
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 3
Abstract
In this study, the anti-inflammatory and analgesic properties of aqueous leaves extract of Carica papaya using formalin induced hind paw edema in rats, and acetic acid induced abdominal writhing in mice was investigated. A total of 25Albino Wistar rats were used for the anti-inflammatory studies and 25 mice where used for the analgesic study. In the anti-inflammatory studies, 25 rats were divided into 5groups of 5rats each. Group I serve as control group and received normal saline, group II, III and IV were administered 25, 50 and 100mg/Kg body weight of the carica papaya leaves extract while group V serves as the positive control group which was administered piroxicam 20mg/kg body weight. For the analgesic study, 25 mice were divided into 5groups of 5mice each. Group I serve as control group and receive normal saline while groups II, III, and IV were administered 25, 50 and 100mg/kg body weight of the carica papaya leaves extract respectively. Group V was administered piroxicam 20mg/kg body weight it serves as the positive control. The results obtained showed a significant reduction in the formalin induced edema in rats administered at the 1st, 2nd, 3rd and 4th hours respectively e.g at the first hour 25mg/kg of the extract 0.59±0.03a as compared to 0.64±0.01,(control), 50mg/kg 0.59±0.02a as compared to 0.64±0.01, 100mg/kg 0.60±0.01a as compared to 0.64±01 and piroxicam 20mg/kg 0.62±0.02a . The extract produced more anti-inflammatory effect than piroxicam 20mg/kg a standard antiinflammatory drug. The analgesic study of the plant extract revealed that the plant extract of carica papaya significantly reduced the writhing reflex in mice which is an indication of analgesic property and it is dose dependent as seen from the result. 25mg/kg 7.20±1.65, 50mg/kg 5.50±2.39, 100mg/kg 4.33±2.84, piroxicam 20mg/kg 5.00±2.44 as compared to the control 17.00±2.09, at 100mg/kg, carica papaya leaves extract have stronger analgesic property than piroxicam 20mg/kg. Therefore, the leaves extract of carica papaya has a strong anti-inflammatory and analgesic property and its analgesic property is dose dependent.
Authors and Affiliations
A. M Danborno, S. H. Ibrahim, M. J. Mallo
Keywords
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- EP ID EP395410
- DOI 10.9790/3008-1303046063
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