The antiulcer effects of the methanol extract of the leaves of <i>aspilia africana</i> (asteraceae) in RATS
Journal Title: African Journal of Traditional, Complementary and Alternative Medicines - Year 2005, Vol 2, Issue 3
Abstract
[i]Aspilia africana,[/i] (Asteraceae) is a plant currently used in Cameroon ethnomedicine for the treatment of stomach ailments. The methanol extract of the leaves of [i]A. africana[/i] was investigated against gastric ulcerations induced by HCl/ethanol and pylorus-ligation. With both methods, the extract inhibited gastric ulcerations in a dose-related manner. Oral administration of the plant extract at the doses of 0.5 and 1 g/kg reduced gastric lesions induced by HCl/ethanol by 79 % and 97 % respectively. The extract at the dose of 1 g/kg reduced gastric lesion in the pylorus ligated rats by 52 % although the gastric acidity remained higher as compared to the control. These findings show that methanol extract of the leaves of [i]A. africana[/i] possess potent antiulcer properties.
Authors and Affiliations
Télesphore Nguelefack, Pierre Watcho, Sylvie Wansi, Ngetla Mbonuh, Dieudonne Ngamga, Albert Kamanyi
Keywords
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