The antiulcer effects of the methanol extract of the leaves of <i>aspilia africana</i> (asteraceae) in RATS
Journal Title: African Journal of Traditional, Complementary and Alternative Medicines - Year 2005, Vol 2, Issue 3
Abstract
[i]Aspilia africana,[/i] (Asteraceae) is a plant currently used in Cameroon ethnomedicine for the treatment of stomach ailments. The methanol extract of the leaves of [i]A. africana[/i] was investigated against gastric ulcerations induced by HCl/ethanol and pylorus-ligation. With both methods, the extract inhibited gastric ulcerations in a dose-related manner. Oral administration of the plant extract at the doses of 0.5 and 1 g/kg reduced gastric lesions induced by HCl/ethanol by 79 % and 97 % respectively. The extract at the dose of 1 g/kg reduced gastric lesion in the pylorus ligated rats by 52 % although the gastric acidity remained higher as compared to the control. These findings show that methanol extract of the leaves of [i]A. africana[/i] possess potent antiulcer properties.
Authors and Affiliations
Télesphore Nguelefack, Pierre Watcho, Sylvie Wansi, Ngetla Mbonuh, Dieudonne Ngamga, Albert Kamanyi
Keywords
Related Articles
- EP ID EP83564
- DOI -
- Views 127
- Downloads 0
Acute toxicitty and sleep-wake eeg analysis of <i>stachtarpheta cayennensis</i> (verbenaceae) in rodents
This study was carried out in order to establish the scientific basis of the reported ethno-medicinal use of [i]Stachytarpheta cayennensis[/i] (Verbanaceae) as sedative drug. The acute toxicity and barbituric-hypnotic te...
Antitrichomonal activity of 1,3-diaryl-2-propen-1-ones on <i>trichomonas gallinae</i>
1,3-diaryl-2-propen-1-ones were synthesized by the Claisen - Schmidt condensation method. T. gallinae parasites isolated from domestic pigeon were cultured in vitro. The in vitro susceptibility of T. gallinae was evaluat...
TRADITIONAL MEDICINE PRACTICE AMONGST THE IGEDE PEOPLE OF NIGERIA. PART II
A questionnaire-guided ethno-medical survey of the Igede speaking communities of Benue state (Nigeria) was conducted. 90 plant species from 45 families were identified covering 109 recipes against 35 ailments, including...
Neglected diseases in africa: a challenge for medicinal plants research
ANTIHYPERGLYCEMIC EFFECT OF BRIDELIA NDELLENSIS ETHANOL EXTRACT AND FRACTIONS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
The effects of the ethanol extract (1.25 g/kg) and fractions (1 g/kg) of Bridelia ndellensis stem bark on the blood glucose levels in streptozotocin-induced types 1 and 2 diabetic rats at different prandial states were s...