The application of cell cultures, body fluids and tissues in oncoproteomics
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue
Abstract
Mass spectrometry (MS)-based proteomics is a rapidly developing technology for the large scale analysis of proteins, their interactions and subcellular localization. In recent years proteomics has attracted much attention in medicine. Since a single biomarker might not have sufficient sensitivity and specificity in clinical practice, the identification of biomarker panels that comprise several proteins would improve the detection and clinical management of cancer patients. Additionally, the characteristics of protein profiles of most severe human malignancies certainly contribute to the understanding of the biology of cancer and fill the gap in our knowledge of carcinogenesis. This knowledge also is likely to result in the discovery of novel potential cancer markers and targets for molecular therapeutics. It is believed that the novel biomarkers will help in the development of personalized therapy tailored to the individual patient and will thereby reduce the mortality rate from cancer. In this review, the use of different types of human clinical samples (cell cultures, tissues and body fluids) in oncoproteomics is explained and the latest advances in mass spectrometry-based proteomics biomarker discovery are discussed.
Authors and Affiliations
Kamila Duś-Szachniewicz, Paweł Ostasiewicz, Marta Woźniak, Andrzej Gamian
Keywords
Related Articles
- EP ID EP67518
- DOI -
- Views 102
- Downloads 0
Związek wybranych polimorfizmów genów z metabolizmem statyn, ryzykiem udaru niedokrwiennego mózgu i chorób sercowo-naczyniowych
Wpływ propofolu na parametry stanu oksydacyjno-antyoksydacyjnego narządów obwodowych w modelu doświadczalnym u szczurów z chorobą Parkinsona
Inhibitory polimerazy poli(ADP-rybozy) (PARP) w terapii nowotworów z mutacjami BRCA1/2
W obecnie stosowanych terapiach przeciwnowotworowych wykorzystywane są przede wszystkim związki wprowadzające uszkodzenia do DNA. Skuteczność leczenia nowotworów uzależniona jest więc od wydajności mechanizmów związanyc...
Aktywność przeciwbakteryjna/przeciwbiofilmowa „przeterminowanych” płytek krwi i produktów ich degranulacji
The role of biological sciences in understanding the genesis and a new therapeutic approach to Alzheimer’s disease
The paper contrasts the historical view on causal factors in Alzheimer’s disease (AD) with the modern concept of the symptoms’ origin. Biological sciences dealing with cell structure and physiology enabled comprehensio...