The application of fuorescein sodium for the microscopic resection of medulloblastoma
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 5
Abstract
[Objective] To investigate the safety and efficacy of sodium fluorescein-guided microsurgery in children with medulloblastoma, and to analyze the surgical efficacy and prognosis.Among them, 12 cases underwent unilateral telovelar approach,2 cases underwent bilateral telovelar approach, and 6 cases underwent telovelar approach combined with transvermian approach. The intraoperative dose of sodium fluorescein was 2 mg/kg. [Methods] The clinical data of 20 patients with medulloblastoma treated with fluorescein sodium assisted microsurgery from January 2018 to August 2023 in Xinjiang Autonomous Region People's Hospital were retrospectively analyzed. [Results] Of the 20 patients, 12 were male and 8 were female. The mean age of onset was (7.9±3.7) years. In all cases, there was clear tumor fluorescence, none of the cases had adverse reaction associated with the use of sodium fluorescein. There were 16 cases of gross-total resection, 3 cases of near-total resection, 1 case of partial resection, 1 case of intracranial infection, 2 case of subcutaneous effusion, 2 cases of cerebellar mutism. The follow-up time was from 3 to 72 months. 5 cases did not receive sufficient radiotherapy and chemotherapy, and 9 cases died due to tumor progression or recurrence. In all cases, the longest overall survival was 72 months, the mean survival time was 39.2 months, and the median survival time was 41.2 months. [Conclusion] Fluorescein sodium assisted microsurgery is safe and effective in pediatric medulloblastoma surgery.
Authors and Affiliations
Xiaoyuan HUANG, Shijun TANG, Wulabieke MAOLITI, Mamatemin TOHTI, Cheng ZHANG, Shanshan JI, Yonggang WU, Jichao. WANG
Keywords
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- EP ID EP750498
- DOI 10.3969/j.issn.1002-0152.2024.05.007
- Views 23
- Downloads 0
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