Investigating the distant thalamic and substantia nigra damage in patients with cerebral infarction based on voxel morphology analysis
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 4
Abstract
[Objective] To explore the clinical values of voxel-based morphometry (VBM) analysis in magnetic resonance imaging (MRI) for detecting secondary damage to the distant thalamus and substantia nigra in patients with cerebral infarction. [Methods] A total of nineteen patients with first-time unilateral middle cerebral artery (MCA) ischemic stroke were prospectively recruited. Three-dimensional whole-brain MRI scans were performed at 1 week, 1 month, and 3 months after onset. VBM analysis was used to analyze changes in the thalamus and substantia nigra volumes. [Results] VBM analysis revealed that compared to ipsilateral thalamic volume at 1 week after onset, ipsilateral thalamic volume was significantly reduced at 1 month or 3 months after onset (reduced by 637 mm3 and 1488 mm3, respectively; P<0.01), with the atrophy primarily located in the dorsomedial nucleus of the thalamus. Similarly, compared to ipsilateral substantia nigra volume at 1 week after onset, the ipsilateral substantia nigra volume was significantly reduced at 1 month or 3 months after onset (reduced by 64 mm3 and 76 mm3, respectively; P<0.05). [Conclusions] VBM technology can be used to evaluate the ipsilateral thalamic and substantia nigra volume reduction in patients with cerebral infarction in the MCA supply area at 1-3 months after stroke, and to detect secondary damage.
Authors and Affiliations
Danxia CHEN, Bingdong XU, Fengling PI, Yusheng. ZHANG
Keywords
Related Articles
- EP ID EP750487
- DOI 10.3969/j.issn.1002-0152.2024.04.003
- Views 23
- Downloads 0
The clinical value of visual evoked potential in assessing visual pathway of visual hallucinations in Parkinson disease
[Objective] This research was to evaluate the integrity of visual pathways in patients with Parkinson disease (PD) by visual evoked potential (VEP), especially those with visual hallucinations. [Methods] A total of 76 PD...
Advances in morphology-based image post-processing techniques in the diagnosis and management of focal cortical dysplasia
Focal cortical dysplasia (FCD) is one of the most common etiologies leading to drug-resistant epilepsy (DRE), and its neuroimaging features are an important part of clinical evaluation. Only some types of FCD can show ab...
Investigating the distant thalamic and substantia nigra damage in patients with cerebral infarction based on voxel morphology analysis
[Objective] To explore the clinical values of voxel-based morphometry (VBM) analysis in magnetic resonance imaging (MRI) for detecting secondary damage to the distant thalamus and substantia nigra in patients with cerebr...
A case of spinocerebellar ataxia type 8 presenting with multiple system atrophy cerebral type
We report a case of spinocerebellar ataxia type 8 (SCA8) presenting with multisystem atrophic phenotype. The patient was a 57-year-old male with a 4-year course of illness with dizziness and ataxia as the first symptoms,...
Research status of non-drug treatment of vestibular migraine
Due to the limitations of drug treatment of vestibular migraine VM,the exploration of non-drug treatment is particularly important. In recent years,the research on non-drug treatment of VM mainly focuses on four aspects:...