Investigating the distant thalamic and substantia nigra damage in patients with cerebral infarction based on voxel morphology analysis
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 4
Abstract
[Objective] To explore the clinical values of voxel-based morphometry (VBM) analysis in magnetic resonance imaging (MRI) for detecting secondary damage to the distant thalamus and substantia nigra in patients with cerebral infarction. [Methods] A total of nineteen patients with first-time unilateral middle cerebral artery (MCA) ischemic stroke were prospectively recruited. Three-dimensional whole-brain MRI scans were performed at 1 week, 1 month, and 3 months after onset. VBM analysis was used to analyze changes in the thalamus and substantia nigra volumes. [Results] VBM analysis revealed that compared to ipsilateral thalamic volume at 1 week after onset, ipsilateral thalamic volume was significantly reduced at 1 month or 3 months after onset (reduced by 637 mm3 and 1488 mm3, respectively; P<0.01), with the atrophy primarily located in the dorsomedial nucleus of the thalamus. Similarly, compared to ipsilateral substantia nigra volume at 1 week after onset, the ipsilateral substantia nigra volume was significantly reduced at 1 month or 3 months after onset (reduced by 64 mm3 and 76 mm3, respectively; P<0.05). [Conclusions] VBM technology can be used to evaluate the ipsilateral thalamic and substantia nigra volume reduction in patients with cerebral infarction in the MCA supply area at 1-3 months after stroke, and to detect secondary damage.
Authors and Affiliations
Danxia CHEN, Bingdong XU, Fengling PI, Yusheng. ZHANG
Keywords
Related Articles
- EP ID EP750487
- DOI 10.3969/j.issn.1002-0152.2024.04.003
- Views 2
- Downloads 0
Altered gut microbiota and their metabolites in patients with myasthenia gravis
ObjectiveThis study investigated whether gut microbiota and its metabolites are altered in myasthenia gravis (MG) patients.MethodsWe collected fresh stool specimens from MG patients and healthy controls. 16S rRNA gene se...
The expert consensus on clinical diagnosis and treatment of bodily distress disorder
Bodily Distress Disorder (BDD) is a mental disorder characterized by the persistent presence of somatic symptoms. Patients experience profound suffering related to these bodily discomforts. However, the recognition, diag...
A case of Lambert-Eaton myasthenia syndrome with the onset of ataxia
Lambert-Eaton myasthenic syndrome (LEMS) is an immune-mediated disorder involving neuromuscular junctions, characterized by muscle weakness, autonomic dysfunction, and reduced tendon reflexes. We report a LEMS case prese...
Study on the mechanism of losartan reducing the risk of comorbid depression in epileptic rats
[Objective] To investigate the effectiveness and mechanisms of losartan in improving comorbid depression in epileptic rats. [Methods] Male rats were randomly divided into three groups: The losartan-pilocarpine group (PL-...
A study on the correlation between childhood trauma, resilience and non-suicidal self-injury in adolescents
[Objective] To explore association between childhood trauma, resilience and non-suicidal self-injury in adolescents. [Methods] One hundred and fifty-eight first-episode adolescent patients with mood disorders were select...