Investigating the distant thalamic and substantia nigra damage in patients with cerebral infarction based on voxel morphology analysis
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 4
Abstract
[Objective] To explore the clinical values of voxel-based morphometry (VBM) analysis in magnetic resonance imaging (MRI) for detecting secondary damage to the distant thalamus and substantia nigra in patients with cerebral infarction. [Methods] A total of nineteen patients with first-time unilateral middle cerebral artery (MCA) ischemic stroke were prospectively recruited. Three-dimensional whole-brain MRI scans were performed at 1 week, 1 month, and 3 months after onset. VBM analysis was used to analyze changes in the thalamus and substantia nigra volumes. [Results] VBM analysis revealed that compared to ipsilateral thalamic volume at 1 week after onset, ipsilateral thalamic volume was significantly reduced at 1 month or 3 months after onset (reduced by 637 mm3 and 1488 mm3, respectively; P<0.01), with the atrophy primarily located in the dorsomedial nucleus of the thalamus. Similarly, compared to ipsilateral substantia nigra volume at 1 week after onset, the ipsilateral substantia nigra volume was significantly reduced at 1 month or 3 months after onset (reduced by 64 mm3 and 76 mm3, respectively; P<0.05). [Conclusions] VBM technology can be used to evaluate the ipsilateral thalamic and substantia nigra volume reduction in patients with cerebral infarction in the MCA supply area at 1-3 months after stroke, and to detect secondary damage.
Authors and Affiliations
Danxia CHEN, Bingdong XU, Fengling PI, Yusheng. ZHANG
Keywords
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- EP ID EP750487
- DOI 10.3969/j.issn.1002-0152.2024.04.003
- Views 25
- Downloads 0
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