The ARG399GLN Polymorphism in DNA Repair Gene XRCC1 Does Not Alter Risk of Parkinson's Disease

Journal Title: Journal of Neurological Sciences-Turkish - Year 2009, Vol 26, Issue 2

Abstract

The etiology of Parkinson's disease (PD), a neurodegenerative disorder, is still unknown and the role of genetic factors have been implicated. XRCC1 (X-Ray Repair Cross-Complementingin) protein is required for DNA single-strand break repair and interacts with poly-ADP-ribose-polymerase (PARP), DNA-ligase III and DNA polymerase beta. It has been shown by mouse models that PARP may have a role in the pathogenesis of various diseases including PD. The aim of the study is to investigate the association of PD with XRCC1 gene Arg399Gln polymorphism. Seventy-one unrelated PD patients (50 male, 21 female) and 76 healthy age and sex matched volunteers (53 male, 23 female) have been included in the study. Molecular analyses have been performed with Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) methods. The relationship between the XRCC1 gene Arg399Gln polymorphism and the PD risk has been investigated with the binary logistic regression analysis. No statistically significant relation has been determined between the PD and control groups (p=0,364). The present study is the first research about the relationship between the DNA repair genes and PD in the literature and does not show any relationship between PD and XRCC1 gene Arg399Gln polymorphism in Turkish population. Further studies with larger sample sizes will reveal more information about the genetic polymorphisms in DNA repair genes for the risk and the etiopathogenesis of PD.

Authors and Affiliations

Hakan KALEAGASI, Tuba EDGUNLU, Mehmet ERDAL, Okan DOGU

Keywords

Related Articles

Surgery Decision in Brainstem Mass Resection by Diffusion Tensor Based Fiber Tracking Assistance: A Report of Four Cases 

Brainstem is surrounded by noteworthy dense packed white matter fibers which must be preserved during surgery. Brain stem surgery carries serious risks. It is very important to know about the localization of the tumor an...

Acute Encephalopathy Associated With H1N1 Infection: A Case Report

We report a 20 year old previously healthy male patient presented with high fever, headache, speech disorder, disorientation, and epileptic seizure. Clinical presentation, cerebrospinal fluid, and magnetic resonance imag...

Effects of Erythropoietin on The Volume of Infarction After Spinal Cord Ischemia Model 

Background: In this study we aimed to investigate the effects of intravenous erythropoietin on motor neuron cells and volume of infarction in a rabbit model of spinal cord ischemia of 40 minutes. Methods: Seventeen New...

Bilateral Lomber Disk Kompresyonunda Unılateral Yaklaşımla İki Taraflı Mikroinvasif Dekompresyonu (Kontralateral Diskektomi )Tekniği: Yeni Bir Teknik ve Klinik Çalışma

Amaç: İki yanlı lomber disk herniasyonlu olgular nöroşirürji pratiğinde nadirdir. İki yanlı lomber disk hastalığında iki taraflı açılım laminotomi ve diskektomi ile yapılmaktadır. Bu tekniğin dezavantajları mevcüttur. Bu...

Benign Multiple Sclerosis: A Retrospective Survey and Evaluation of Descriptive Clinical Criteria

A reasonable amount of multiple sclerosis (MS) patients exhibit a benign course. The patients who can lead an independent life with a low EDSS score less than 3,5 after ten years or longer disease duration are regarded t...

Download PDF file
  • EP ID EP96859
  • DOI -
  • Views 114
  • Downloads 0

How To Cite

Hakan KALEAGASI, Tuba EDGUNLU, Mehmet ERDAL, Okan DOGU (2009). The ARG399GLN Polymorphism in DNA Repair Gene XRCC1 Does Not Alter Risk of Parkinson's Disease. Journal of Neurological Sciences-Turkish, 26(2), 185-189. https://europub.co.uk/articles/-A-96859