The Association Between Latent Membrane Protein-1 and CD80, CD86, MHC-I and CD8 in Advanced Stage Nasopharyngeal Carcinoma
Journal Title: Turkish Journal of Immunology - Year 2017, Vol 5, Issue 3
Abstract
Introduction: This study aimed to investigate the escape mechanism of tumor cell to host immune system via CD80, CD86, MHC Class I and CD8 in advanced stage nasopharynx carcinoma. Materials and Methods: This cross-sectional analytical observational study was conducted in 434 nasopharynx carcinoma (NPC) patients who visited Otorhinolaryngology Outpatient clinic of Dr. Moewardi Hospital from 2011 to 2014. The data were obtained from medical record system and histopathologic examination results. The sample collection was obtained by consecutive sampling. The expressions of CD80, CD86, MHC Class I and CD8 were assessed by immunohistochemistry staining (IHC). Results: Of the total study subjects, we found 32 sample of Grade 3 NPC, and the statistical analysis of these sample revealed that although there was no statistically significant association between the expression of latent membrane protein 1 (LMP1) and CD8 (p=0.556), and expression of CD80, there was a statistically significant association between LMP1 and CD86 (p=0.034). Similarly, although no statistically significant association was found between expression of CD8 and LMP1 (p=0.053), MHC Class I expression was found statistically significantly associated with LMP expression (p=0.012). Conclusion: The effect of LMP1 on CD8 mediated by CD86, MHC Class I is statistically significant in which the increase of LMP1 expression is followed by the decrease of CD8 expression. Thus it suggests the concept of escape mechanism. Keywords: Escape mechanism, nasopharyngeal carcinoma, World Healt Organization Type 3 advanced stage, latent membrane protein-1(LMP1), MHC Class I, CD80, CD86
Authors and Affiliations
Made Setiamika, Edi Wijajanto, Aris Widodo, Pudji Rahayu
Keywords
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- EP ID EP449980
- DOI 10.25002/tji.2017.581
- Views 105
- Downloads 0
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