The clinical course of chronic pancreatitis in children with the coincidence of mutations in the CFTR and SPINK1 genes
Journal Title: Postępy Nauk Medycznych - Year 2014, Vol 27, Issue 3
Abstract
Introduction. The causes of chronic pancreatitis (CP) in children are varied. These include gene mutations, anatomic anomalies of the pancreatic duct and metabolic disorders.Aim. The aim of our study was to evaluate the clinical severity of chronic pancreatitis in children with the coincidence of mutations in the CFTR gene and SPINK1 gene.Material and methods. 208 children with chronic pancreatitis were enrolled into the study. Data were analyzed for age at diagnosis, severity of inflammatory lesions assessed on a Cambridge scale during ERCP and the frequency of intervention treatment. All the children had carried out the analysis of PRSS1, CFTR and SPINK1 gene mutations.Results. The coincidence of mutations in CFTR and SPINK1 genes was found in 9 children (4.3%). There was no significant difference in the age of the disease onset between the studied group and the rest of the patients (9 years vs. 8.9 years, NS). There was no difference in the severity of inflammatory lesions assessed on a Cambridge scale during ERCP (1.5 vs. 1.7, NS). The frequency of therapeutic procedures (endoscopic and surgical) (38 vs. 35%, NS), pancreatic duct stenting (38 vs. 35%, NS) and the frequency of ESWL were also similar in both groups of patients.Conclusions. The clinical course of chronic pancreatitis in children with the coincidence of mutations in the CFTR and SPINK1 genes does not differ from the clinical course of disease caused by other etiological factors.
Authors and Affiliations
Karolina Wejnarska, Jarosław Kierkuś, Elwira Kołodziejczyk, Józef Ryżko, Grzegorz Oracz
Keywords
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