The Clinical Significance of the Neutrophil-to-Lymphocyte Ratio in Patients with Guillain-Barré Syndrome Independent of Infection
Journal Title: Medical Science and Discovery - Year 2016, Vol 3, Issue 8
Abstract
Objective: In the present study, we aimed to determine the predictive value of neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of Guillain-Barré Syndrome (GBS). Material and Methods: This retrospective study enrolled 94 GBS patients and a control group of 101 healthy subjects.Results: GBS patients had significantly higher NLR, C- Reactive Protein (CRP) and Erythrocyte Sedimentation Rate (ESR) values at presentation than the healthy control group (p < 0.001, p < 0.001, p < 0.001, respectively). Patients unresponsive to IVIg therapy had significantly higher NLR values at the time of admission in comparison to responsive patients (p=0.001). NLR was significantly and positively correlated with the disease severity, CRP and ESR. A receiver operating characteristic (ROC) analysis of the ability of NLR to predict GBS showed a cutoff value of 3.5 (sensitivity 62.8%, specificity 90.1%). The cutoff value was 11 for CRP (sensitivity 52.7%, specificity 86%) and 12.3 for ESR (sensitivity 51.3%, specificity 82%). Exclusion of patients with signs of infection at presentation gave a NLR value of 3.2, which had a sensitivity of 61.6% and a specificity of 89.8% for predicting GBS.Conclusion: Whereas ESR and CRP lost their significance in predicting GBS. Unlike ESR and CRP, NLR might be a promising marker in GBS regardless of infection.
Authors and Affiliations
Sirma Geyik, Hakan Bozkurt, Münife Neyal, Remzi Yigiter, Samiye Kuzudisli, Seval Kul
Keywords
Related Articles
- EP ID EP520529
- DOI 10.17546/msd.90383
- Views 44
- Downloads 0
Transient ischemic attack after Mesobuthus gibbosus envenomation
Endometriosis Mesobuthus gibbosus is a medically important venomous scorpion in western of Turkey which causes significant morbidity. Envenoming of this species scorpion results with varying degrees of local symptoms and...
The relation of Hereditery Multiple Exostoses and trace elements
Introduction: Hereditery multiple exostoses (HME) is a rarely autosomal dominant bone tumoral disorder; which is characterized by abnormal ossification especially at long bones. The common symptoms are bone pain, joint m...
Familial Recurrent Hydatidiform Moles: A rare case report
Recurrent hydatidiform moles (RHM) are described as the being of at least two molar pregnancies in the same patient. It is very rare. NLPR7 mutations are found high rate in patients with RHM. KHDC3L is the second respons...
What is the amniotomy effect on non stress test in patients meconium stained amniotic fluid?
Objective: Meconium stained amniotic fluid is a frequently encountered situation, it can really disturb an obstetrician, as it increases the rates of neonatal morbidity and mortality and it is difficult to prevent meconi...
Ecthyma Gangrenosum in a Pediatric Patient and Review of the Literature
Erythema Gangrenosum (EG), is an infective lesion of skin, and mucous membranes typically occurring in patients with chronic disease or immunocompromised patients. İt is a very rarely seen vasculitis with a potentially p...