The Clinical Significance of the Neutrophil-to-Lymphocyte Ratio in Patients with Guillain-Barré Syndrome Independent of Infection
Journal Title: Medical Science and Discovery - Year 2016, Vol 3, Issue 8
Abstract
Objective: In the present study, we aimed to determine the predictive value of neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of Guillain-Barré Syndrome (GBS). Material and Methods: This retrospective study enrolled 94 GBS patients and a control group of 101 healthy subjects.Results: GBS patients had significantly higher NLR, C- Reactive Protein (CRP) and Erythrocyte Sedimentation Rate (ESR) values at presentation than the healthy control group (p < 0.001, p < 0.001, p < 0.001, respectively). Patients unresponsive to IVIg therapy had significantly higher NLR values at the time of admission in comparison to responsive patients (p=0.001). NLR was significantly and positively correlated with the disease severity, CRP and ESR. A receiver operating characteristic (ROC) analysis of the ability of NLR to predict GBS showed a cutoff value of 3.5 (sensitivity 62.8%, specificity 90.1%). The cutoff value was 11 for CRP (sensitivity 52.7%, specificity 86%) and 12.3 for ESR (sensitivity 51.3%, specificity 82%). Exclusion of patients with signs of infection at presentation gave a NLR value of 3.2, which had a sensitivity of 61.6% and a specificity of 89.8% for predicting GBS.Conclusion: Whereas ESR and CRP lost their significance in predicting GBS. Unlike ESR and CRP, NLR might be a promising marker in GBS regardless of infection.
Authors and Affiliations
Sirma Geyik, Hakan Bozkurt, Münife Neyal, Remzi Yigiter, Samiye Kuzudisli, Seval Kul
Keywords
Related Articles
- EP ID EP520529
- DOI 10.17546/msd.90383
- Views 32
- Downloads 0
The Effect of Group-Discussion on the Nurses' Performance of Patients' Rights
Objective: Group discussion enhances the knowledge and the quality of cares provided for patients and reinforces nurses' skills and diagnostic reasoning, its effect on changing and respecting patients' right has though b...
Potential Effects of EGFR Exon 21 L858R Mutations in Lung Cancer
Objective: The mainly significant reason in the etiology of lung cancer is smoking, which is important in other environmental pollutants and genetic susceptibility. Lung cancer is separated two major groups as mainly non...
The effect of gel foam mattress use during total hip replacement surgeries on the development of pressure ulcers in the recovery unit: a quasi-experimental study
Objective: This study was conducted on patients undergoing total hip replacements in order to examine the effect of the use of a gel foam mattress during surgery on preventing the development of pressure ulce...
Urinary tract infections in newborns
The incidence of neonatal urinary tract infection (UTI) varies from 0.1 to 1% of all infants, and its frequency is inversely proportional to birth weight [1]. Neonatal UTI presents different features than those observed...
A case of zellweger syndrome accompanied by hypertrophic cardiomyopathy
Peroxisomal biogenesis disorders are a group of genetically and clinically heterogenous disorders which affect very-long chain fatty acid metabolism. Zellweger syndrome (ZS) is a rare, congenital disorder characterized b...