The Clinicopathological Findings of 121 Patients Presenting with Spontaneous Nipple Discharge
Journal Title: Istanbul Medical Journal - Year 2021, Vol 22, Issue 2
Abstract
Introduction: This study aimed to investigate the cytopathological findings of patients who presented to our hospital with spontaneous nipple discharge. A cytological smear examination was performed to evaluate the correlation between cytology and biopsy in patients whose complementary biopsy or excision sampling was performed. Methods:The nipple discharge smears of 121 patients sent to us over six years were retrospectively reviewed. Acellular smears without any cells were considered “insufficient”, and smears that contained ductal cells, inflammatory cells, and foamy histiocytes were considered “sufficient”. Smears considered sufficient for microscopic evaluation were classified and reported as “benign cytology”, “compatible with papillary lesion”, “suspicious for malignancy”, and “malignant cytology”. Results: When the first smear samples of 121 patients were examined, “malignant cytology” was observed in one patient, “suspicious for malignancy” in two patients, “ductal ectasia” in one hundred and two patients, and “papillary lesion” in fourteen patients. The material was “acellular” in two patients. Nineteen patients were histopathologically diagnosed with malignancy (n=7), ductal ectasia (n=6), intraductal papilloma accompanied by florid-type intraductal hyperplasia without atypia (n=2), intraductal papilloma (n=2), complex sclerosing lesion (n=1), and sclerosing papilloma (n=1). Conclusion: In cases where nipple discharge is persistent, repeated smear samples may contribute to the diagnosis if they contain epithelial components. In cases with histopathologically confirmed breast carcinoma, it should be kept in mind that the tumor may often show neuroendocrine features.
Authors and Affiliations
Buket Bambul Sığırcı, Canan Kelten Talu, Yasemin Çakır, Cem Leblebici, Didem Can Trabulus
Keywords
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