The current knowledge of immune privilege in stem cells
Journal Title: Journal of Transplantation & Stem Cell Biology - Year 2014, Vol 1, Issue 1
Abstract
Immune privilege as an active defensive mechanism guards cells and tissues against foreign antigens. Developing tumors and adult stem cells are believed to be immune privileged, since they have the ability to avoid rejection after implantation. Allograft rejection of transplanted tissues and organs occurs because of allelic differences between graft and host at polymorphic loci, which give rise to histocompatibility antigens; unless immunosuppressive therapy is given. This obstacle also exists when using human embryonic stem cell for cell transplantation, rising challenges in cell therapy and in regenerative medicine. Therefore, to better understand the mechanisms underlying in immune privilege and to obtain strategies which can mimic the naturally immune privileged cells, is of utmost significance in transplantation and regenerative medicine.
Authors and Affiliations
Yong Li
Keywords
Related Articles
- EP ID EP207550
- DOI 10.13188/2374-9326.1000002
- Views 125
- Downloads 0
Scaffold Free 3D Culture of Mesenchymal Stem Cells; Implications for Regenerative Medicine
Mesenchymal stem cells (MSCs) are recognized as important sources for regenerative medicine (RM). Adherent cultures, long time considered definitory for MSCs phenotype, are relatively easy to perform and to assess. Two d...
Organ Bioengineering, Regeneration and Repair: Where the Future of Organ Transplantation is Taking Shape
Although organ transplantation is now widely viewed as one of the monumental achievements in the history of modern medicine, that was not always the case. Indeed, back at the beginning of the 20th century the idea of rep...
Regulation of Hypoxia-Induced Cell Death and Application of Hypoxic Preconditioning to Stem Cell Transplantation
Hypoxia is a commonly encountered feature of the cellular microenvironment in a number of processes in which programmed cell death (apoptosis) affects disease progression. These diseases include myocardial infarction, st...
Cognitive Changes after Cellular Therapy in a Case of Intellectual Disability
Intellectual Disability (ID) is a developmental disability characterized by sub average intellectual functioning, occurring in 2-3% of the population. The underlying cause in ID is the sub-functioning of the neurons whic...
Stem Cell Therapies in Regenerative Medicine and Diabetes Mellitus: Advances, Constraints and Future Prospects
Stem cell therapy is one of the most promising treatments for the near future. This kind of therapy can ameliorate or even reverse some diseases and have potential applications in regenerative and replacement medicines a...