Regulation of Hypoxia-Induced Cell Death and Application of Hypoxic Preconditioning to Stem Cell Transplantation
Journal Title: Journal of Transplantation & Stem Cell Biology - Year 2015, Vol 2, Issue 1
Abstract
Hypoxia is a commonly encountered feature of the cellular microenvironment in a number of processes in which programmed cell death (apoptosis) affects disease progression. These diseases include myocardial infarction, stroke, and ischemic acute kidney injury. Bone marrow-derived mesenchymal stem cells (MSCs) are multipotent adult stem cells that are able to differentiate into endothelial cells, vascular smooth muscle cells, or cardiac-like myocytes when transplanted into the ischemic heart. Both animal and clinical studies have substantiated that MSC transplantation can enhance cardiac function through possible angiogenesis and myogenesis after myocardial infarction. However, some studies have failed to monitor the therapeutic effects of MSC transplantation; therefore, there is a need for supplementary research on the use of MSCs and the improvement of transplantation techniques after MI. An important problem in stem cell therapy for ischemic heart diseases is the low survival of transplanted cells in the ischemic and infarcted sites. Most transplanted cells die within 4 days after transplantation into the ischemic heart. Endogenous and environmental factors, such as hypoxia and inflammatory response, may contribute to cell death. Therefore, enhancing implanted cell survival after transplantation is vital for improving the effect and efficiency of stem cell therapy. In this review, we investigate whether hypoxia is responsible for activating apoptosis signaling in transplanted stem cells, and could be a potential target for enhancing the therapeutic effect of stem cells in treating ischemic heart diseases.
Authors and Affiliations
Sang Hun Lee
Keywords
Related Articles
- EP ID EP207557
- DOI 10.13188/2374-9326.1000006
- Views 118
- Downloads 0
Cognitive Changes after Cellular Therapy in a Case of Intellectual Disability
Intellectual Disability (ID) is a developmental disability characterized by sub average intellectual functioning, occurring in 2-3% of the population. The underlying cause in ID is the sub-functioning of the neurons whic...
Scaffold Free 3D Culture of Mesenchymal Stem Cells; Implications for Regenerative Medicine
Mesenchymal stem cells (MSCs) are recognized as important sources for regenerative medicine (RM). Adherent cultures, long time considered definitory for MSCs phenotype, are relatively easy to perform and to assess. Two d...
Generation of Neural Cells by Direct Cellular Reprogramming
Cellular reprogramming is a new technique that is currently explored for its potential to manufacture human cell types in vitro. Direct cellular reprogramming allows the direct conversion of cells into a target cell type...
Regulation of Hypoxia-Induced Cell Death and Application of Hypoxic Preconditioning to Stem Cell Transplantation
Hypoxia is a commonly encountered feature of the cellular microenvironment in a number of processes in which programmed cell death (apoptosis) affects disease progression. These diseases include myocardial infarction, st...
First Results on Three Patients Treated with Topical Recombinant Human Erythropoietin (rhEPO) to Improve Wound Healing in Diabetic Foot Ulcers
Chronic wounds not only induce individual distress but also cause enormous and rapidly growing costs for our health care systems and society in general. The fastest growing groups of chronic wounds are Diabetic Foot Ulce...