The drug-induced injury of the upper gastrointestinal tract: prophylaxis and treatment
Journal Title: Сучасна гастроентерологія - Year 2019, Vol 0, Issue 2
Abstract
It is well established that non-steroidal anti-inflammatory drugs (NSAIDs) are the causal factor of mucosa damage not only of in the stomach and duodenum, but also in esophagus, triggering the development of gastroesophageal reflux disease (GERD). It is known that NSAIDs’ intake (including low doses of aspirin) can significantly increase the likelihood of developing of the peptic esophagitis with the risk of ulceration, bleeding, or stricture formation. Recent years, there is an increasing number of papers, devoted to the investigation of esophageal lesions and mechanisms of GERD development, occurring during the NSAIDs’ administration (including low doses of acetylsalicylic acid) and other drugs. The structure of drug-induced lesions of the upper gastrointestinal tract in patients taking NSAIDs has been analyzed. The investigation has been performed to study the frequency and characteristics of esophageal lesions in patients with osteoarthrosis of large joints, receiving NSAID treatment, as well as to determine factors that increase risk of developing this pathology. With account of the considered risk factors, the most rational approach to the diagnosis and primary prevention of NSAID-induced esophagitis has been chosen, which in most cases should reduce the incidence of side effects of NSAID-associated lesions of the esophagus. The main directions in the treatment of NSAID-associated injuries of the esophagus, namely, lifestyle change, balanced diet, changing the dose and regimen of NSAIDs or switching to selective NSAIDs, modern pharmacotherapy and surgical treatment have been elucidated. Clinical examples of patients with esophagus and stomach injuries associated with the long-term administration of NSAIDs and antiplatelet drugs were used to discuss the prevention and treatment of this category of patients, using proton pump inhibitors and bismuth-containing drugs.
Authors and Affiliations
O. O. Bondarenko, O. M. Agibalov
Keywords
Related Articles
- EP ID EP575132
- DOI 10.30978/MG-2019-2-55
- Views 119
- Downloads 0
A place of plasma substitutes in the treatment of patients with chronic viral hepatitis
Objective — to assess the efficacy of plasma substitute (Reosorbilact) in patients with chronic viral hepatitis. Materials and methods. The investigation involved 60 patients with chronic viral hepatitis (CVH), who were...
Nutrigenetic characteristics of patients with nonalcoholic liver disease combined with metabolic syndrome
Objective — to detect possible association of polymorphisms of the Pro12Ala of PPARG2 gene (rs1801282) and ADRB3 gene (rs4994) with a degree of fatty liver and metabolic disorders in patients with NAFLD. Materials and m...
Changes in the microcrystallization of oral fluid in the dynamics of treatment of catarrhal gingivitis in adolescents with chronic gastroduodenitis
Objective — to study the changes of microcrystallization of saliva in adolescents with chronic gastroduodenitis in the process of complex treatment of generalized catarrhal gingivitis. Materials and methods. The type of...
Gastroesophageal reflux disease in patients with metabolic syndrome: the peculiarities of clinical course and the modern approaches to treatment
The article presents a data on prevalence of gastroesophageal reflux disease and Barrett’s esophagus in patients with metabolic syndrome. The main etiopathogenetic mechanisms of formation and modern approaches to therapy...
Predictors of irritable bowel syndrome formation among students
Objective — to establish the role of the nervous system disorders in the formation of irritable bowel syndrome (IBS) among students. Materials and methods. Examination involved 32 students with IBS, aged 19 to 26 years....