A place of plasma substitutes in the treatment of patients with chronic viral hepatitis
Journal Title: Сучасна гастроентерологія - Year 2019, Vol 0, Issue 2
Abstract
Objective — to assess the efficacy of plasma substitute (Reosorbilact) in patients with chronic viral hepatitis. Materials and methods. The investigation involved 60 patients with chronic viral hepatitis (CVH), who were divided into 2 groups: 35 patients of the main group received plasma substitute against the background of the basic therapy, and 25 patients of comparison group received only basic therapy. Along with the generally accepted laboratory tests, the special immunological and biochemical tests have been performed. Results. The investigation demonstration good tolerability of the drug and improvement of the immunological indices. The accelerated normalization of immune regulating CD4/CD8 index in patients of the main group (2.03 ± 0.03; p > 0.05) has been revealed, as well as stimulation of the natural infection-resistance factors in the CVH patients. The administration of the plasma substitute in addition to the basic therapy promoted to the significant increase in the liver antitoxic and proteinsynthesizing functions, resulting in more significant reduction in the severity of syndromes of endogenous and infectious toxicosis. Patients’ condition in the main group improved by the 4- 5the day of treatment (at average on the 3.5 ± 0.2 day), whereas in the comparison group this improvement took place by the end of first week. In the number of cases there was no need in the anti-recurrent therapy to avoid the chronic hepatitis exacerbation during one year of the follow-up care, that testified the achievement of the stable clinical and laboratory remission, occurring by 10 — 15 % oftener in the main than in the comparison group. Conclusions. The drug can be considered as a promising agent for the widespread use in the treatment of patients not only with CVH, but also with other diseases of infectious genesis, for the reduction of intoxication, correction of acid-base balance, improvement of microcirculation, as well as for providing of the antiinflammatory, antioxidant and immune corrective effects.
Authors and Affiliations
F. I. Khamrabaeva
Keywords
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- EP ID EP574917
- DOI 10.30978/MG-2019-2-29
- Views 113
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