The Effecst of Vitamin D on Bone

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The Effecst of Vitamin D on Bone

Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 3

Abstract

1,25(OH)&lt;sub&gt;2&lt;/sub&gt;D is a steroid hormone, which encourages the metabolism of calcium and phosphorous. Vitamin D mediates its biological effects by binding to the vitamin D receptor (VDR), which is principally located in the nuclei of target cells.&lt;sup&gt; &lt;/sup&gt;The binding of vitamin D to the VDR allows the VDR to act as a transcription factor that modulates skeletal gene transcription. Numerous direct and indirect effects of 1,25(OH)&lt;sub&gt;2&lt;/sub&gt;D have been demonstrated on a range of critical bone proteins and 1,25(OH)&lt;sub&gt;2&lt;/sub&gt;D appears to be involved in their regulation at all stages of osteoblast differentiation and, indeed, bone remodeling. 1,25(OH)&lt;sub&gt;2&lt;/sub&gt;D uses VDR to regulate calcium absorption leading to increased capacity of the intestine to absorb calcium and acts on the PTH gene to decrease its transcription. Vitamin D deficiency can result in lower bone mineral density and an increased risk of bone fracture. In article was discussed direct and indirect effects of vitamin D on bone.

Authors and Affiliations

Magdalena Walicka, Ewa Czerwińska

Keywords

bone Vitamin D VDR osteoblast osteoclast Osteocyte mineralization

EP ID EP54410
DOI -
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