The Effect of Intra Amygdala Injection of Naloxone on Learning and Memory in Barnes Maze
Journal Title: The 1st Annual Meeting of Georgian Center for Neuroscience Research - Year 2020, Vol 2, Issue 20
Abstract
Background and purpose: The endogenous opioids and their receptors are widely distributed throughout the body. The presence of all opioids receptors in the nervous systems particularly in hippocampus suggests that they could play a role in learning and memory. The amygdala is a key brain structure involves emotional learning and memory. Here we examined the effect of injection of an opioid system antagonist (naloxone) in amygdala on learning and memory. Materials and methods: Male Wistar rats (n=14) were subjected to tow groups, (n=7) sham group and (n=7) the group with injection of naloxone in to amygdala (0.05 and 0.1 µM). The learning and memory was tested in Barnes maze for three consecutive days (sessions) each day consist of 5 trials. Results: The results showed that naloxone could decrease the delay time of reaching the goal box and increase the velocity of it during three day of training (P<0.001).48 hours later in probe day, the memory test indicated better retrieval in naloxone treated animals. There was no difference between two doses of naloxone in day two and three. In conclusion naloxone could improve the learning and memory.
Authors and Affiliations
Farideh Bahrami, Seyd Ali Noorbakhsh, Ali Qarib
Keywords
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- EP ID EP677938
- DOI 10.29088/GCNR-2020.29
- Views 211
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