The Comparison of Executive Functions in Addicts and Patients Under Buprenorphine Maintenance Treatment (BMT)
Journal Title: The 1st Annual Meeting of Georgian Center for Neuroscience Research - Year 2020, Vol 2, Issue 20
Abstract
Introduction: Buprenorphine, a partial opioid agonist of the µ-receptor, is one of the most important developments in pharmacotherapy for opioid addiction. However, there are some clinical and empirical evidence for executive functional impairment of buprenorphine in opioid addicts. This study aimed to evaluate and compare the executive function in opiate users with those who are under buprenorphine therapy. Methods: This study is a cross-sectional survey. 31 patients under buprenorphine maintenance treatment in Semnan Addiction Treatment Clinics, 31 opioid abusers of those referring to the treatment clinics and control group of ordinary people were randomly selected. Data were collected by performing computer version of Stroop and Working Memory Tests on subjects. Multivariate analysis of variance was used to analyze the data. Results: The results indicate greater impairment of working memory and response inhibition in opiate abusers and those under buprenorphine treatment compared to the control group. Deeper investigation showed that patients treated with buprenorphine had better results compared to opioid abusers in working memory and Stroop test. Conclusion: Although patients under buprenorphine treatment show impairments in executive function, but better performances was marked in compare to opioid abusers. Because buprenorphine is a partial agonist, its prescription for opioid addiction treatment probably leads to less disorders of cognitive functions. It seems that more emphasis should be done on the use of buprenorphine maintenance treatment (BMT) in addiction treatment.
Authors and Affiliations
Eghbali Ghahyazi Hamid, Nabavi Farkhonde, Rajabpour Mojtaba, Shokrollahi Hasan
Keywords
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- EP ID EP677956
- DOI 10.29088/GCNR-2020.47
- Views 168
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