The effect of omega-3 polyunsaturated fatty acids enriched diet on the contractile function, structure, Ca2+ handling and electrophysiology in the rat heart
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 6
Abstract
Introduction. Omega-3 polyunsaturated fatty acids (ω-3 PUFA) are essential fatty acids that cannot be synthesized by mammals and must be delivered with food. Epidemiological observations suggest that supplementation of ω-3 PUFA reduces cardiovascular mortality, although results of clinical trials and animal studies are highly variable and inconsistent.Aim. The aim of the study was to examine cardiovascular effects of ω-3 PUFA supplementation in healthy rats. Eicosapentanoic acid (EPA) and docosahexanoic acid (DHA), the two most commonly used ω-3 PUFAs, were used.Material and methods. Rats were fed with normal chow or EPA- or DHA-enriched diet for 4 weeks. Epicardial monophasic action potentials (MAPs) were recorded, cardiomyocyte Ca2+ handling was assessed and eachocardiographic imaging was performed before and after 4 weeks of feeding.Results. Neither EPA nor DHA affected left ventricular (LV) ejection fraction, wall thickness or diameters, indicating that 4 weeks of feeding had no effect on LV structure and function. While EPA enriched diet had no impact on intracellular Ca2+ handling, DHA-rich diet significantly increased amplitude of Ca2+ transient and SR Ca2+ content. Neither EPA nor DHA affected action potential duration, however EPA mildly increased action potential amplitude.Conclusions. This indicates that ω-3 PUFAs are safe for the cardiovascular system, but the above mentioned cellular effects may be considered arrhythmogenic under specific conditions.
Authors and Affiliations
Michał Mączewski, Monika Duda, Mariusz Marciszek, Joanna Kołodziejczyk, Urszula Mackiewicz
Keywords
Related Articles
- EP ID EP77420
- DOI 10.5604/08606196.1158006
- Views 196
- Downloads 0
Hepatobiliary complications in intensive nutrition therapy
Enteral nutrition is (EN) offers the possibility to increase or to insure nutrient intake in case of insufficient oral food intake. Total parenteral nutrition is an effective method for supplying energy and nutrients whe...
Nowoczesne metody terapii trudno gojących się położniczo-ginekologicznych ran pooperacyjnych – analiza przydatności i skuteczności stosowania
Nieprawidłowe gojenie się ran pooperacyjnych stanowi istotny problem medyczny na świecie. Zakażone, przewlekłe i trudno gojące się rany prowadzące do rozejścia powłok w obrębie miejsca operowanego narażają pacjenta na wy...
Waist-to-Height Ratio – an Alternative Index for Evaluating Obesity and Assessing the Cardio-Metabolic Risk. A Study in Warsaw Adolescents
Introduction. Overweight and obesity are well-established causes of increased metabolic and cardio-vascular risk, also in children and adolescents. Since the adverse effects of excess adiposity are believed to be mostly...
Zaburzenia nastroju w chorobach naczyniopochodnych
Zaburzenia nastroju współwystępujące z chorobami naczyniowymi są znaczącym problemem klinicznym. Depresja często współwystępuje z chorobami układu sercowo-naczyniowego ,jest także niezależnym czynnikiem ryzyka wystąpieni...
Clostridium difficile infection as a risk factor in surgery
Ethiology, pathogenesis, clinical symptoms and treatment of Clostridium difficile infection are presented. The increasing incidence of Clostridium difficcile infection due to an excessive and uncontrolled use of antibi...