THE EFFECT OF PHYSICOCHEMICAL FACTORS ON ABSORPTION PROPERTIES OF CERTAIN SPASMOLYTICS IN THE PRESENCE OF DIETARY SUPPLEMENTS CONTAINING CHITOSAN
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2009, Vol 0, Issue
Abstract
Chitosan is used in the treatment of obesity due to its lipid, cholesterol, fatty acids, triglycerides, bile acids binding capacity. A molecule of a cationic polymer, such as chitosan, is capable of binding acid drugs. The aim of the study was to determine the capability of binding spasmolytics: 1-(3,4-dimethoxybenzyl)- 6,7-dimethoxyisoquinoline hydrochloride (Papaverinum hydrochloridum) and [3(S)-endo]-8-methyl-8-azabicyclo[3.2.1]oct-3-nyl ester of a-(hydroxymethyl)- bensoacetic acid (Butylscopolamini butylobromidum) by chitosans present in slimming drugs. Absorption of spasmolytics was investigated with the dynamic method on a biopharmaceutical model imitating in vitro conditions. Mean absorption of drugs on chitosan in relation to environmental pH ranged from 0.1328 g to 0.265 g per 1 g of chitosan for papaverine, and from 0.033 g to 0.330 g per 1 g of chitosan for scopolamine. The highest absorption rates were observed at pH above 7. Concluding, the studies have shown that an interaction occurs between spasmolytics, what decreases the amount and affects the bioavailability of these drugs
Authors and Affiliations
Jan Meler
Keywords
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