The effect of preparatory conditions of high temperature- and pressure-treated garlic on 5-hydroxymethyl-2-furfural
Journal Title: Journal of Analytical Bio-Science - Year 2013, Vol 36, Issue 2
Abstract
We have previously reported that the feeding of high temperature- and pressure-treated garlic (HTPG) reduced preneoplastic lesions at initiation and post-initiation-stage of chemical induced rat colorectal tumor significantly. The HTPG was prepared by using an autoclave (130℃, 150 min). We confirmed that HTPG contained 5-hydroxymethyl-2-furfural (5-HMF) which was metabolized to genotoxic and mutagenic 5-sulfooxymethylfurfural (SMF). On the other hand, HTPG also contains S-allylcysteine (SAC), which has been demonstrated to have chemopreventive effects on a colon cancer model in mice. Therefore, we attempetd to prepare HTPG in new condition and examined the production of 5-HMF and SAC. As a result, we showed that the condition for autoclaving at 130℃ for 60 min may be better than the previous condition.
Authors and Affiliations
Takeshi Chihara
Keywords
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