The effect of vitamin C and vitamin E on oxidative stress and pulmonary function test in the COPD patients
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 10
Abstract
Introduction: Chronic obstructive pulmonary disease (COPD) is a progressive and disabling disorder. Emergence of COPD with a highly significant morbidity and mortality is a serious health care burden in our country. Oxidative stress has been recognized as a central feature of chronic obstructive pulmonary disease (COPD). Aim: Imbalance between oxidant and antioxidant enzymes is also an established fact in COPD patients. But studies in regard to stable COPD patients and effect of vitamin C and vitamin E supplementation are lacking. We studied the effect of vitamin C and vitamin E on the levels of oxidants and antioxidant and pulmonary function test in the COPD patients. Material and Method: Fifty patients with COPD were included in the study. Their baseline clinical examination, spirometry, plasma malondialdehyde (MDA), red blood cell superoxide dismutase (SOD) and erythrocyte glutathione peroxidase (GPx) levels were measured. All the above parameters were repeated after 12 weeks of supplementation with 1000 mg vitamin C and 150 IU of vitamin E daily. Result: Serum MDA levels were significantly lowered, erythrocyte SOD and GPx activity were significantly higher after supplementation of vitamin C and vitamin E. No significant improvement in FEV1 and FEV1/FVC was observed after 12 weeks of vitamin C and vitamin E supplementation. Conclusion: The present study shows that the plasma lipid peroxide (MDA) levels were decreased and antioxidants levels (GPx and SOD) are increased after 12 weeks supplementation of vitamin C and vitamin E in patients with COPD. Exogenous supplementation with vitamin C and vitamin E does not have any significant effect on the spirometric measurements though it brings down the levels of MDA showing attenuation of further damage.
Authors and Affiliations
V R Kathore, S S Jadhav
Keywords
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