The genetics of dementias, Part 3: A molecular basis for the multifactorial inheritance of sporadic Alzheimer’s disease
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2009, Vol 63, Issue
Abstract
The majority of Alzheimer’s disease cases, i.e. more than 85% of the whole population of patients, can be referred to as the sporadic form of the disease, with a negative family history and complex inheritance. As the genetic background of sporadic Alzheimer’s disease is still largely unknown., strategies based on individual genetic risk profiling for either early prediction of the disease or its therapy and prevention are not possible. The APOE*4 allele of the gene for apolipoprotein E is still the only completely confirmed risk factor. Screening for new genetic risk factors with the use of genetic association analysis has many methodological difficulties and limitations. New combined approaches including genomics, proteogenomics, pharmacogenomics, epigenomics, and bioinformatics have to been applied in the future search for a molecular basis of AD. Genetic defects do not fully explain the complexity of the etiopathogenesis of this disease. It is rather certain that environmental factors (through epigenetic modifications in the patient’s epigenome) also have impact on the initiation of neurodegeneration processes. The identification of new genetic and environmental risk factors would make it possible to understand epistatic processes, for example interactions between genes and between genes and environmental factors, responsible for the complex etiology and multifactorial inheritance of sporadic Alzheimer’s disease.
Authors and Affiliations
Anna Kowalska
Keywords
Related Articles
- EP ID EP66401
- DOI -
- Views 202
- Downloads 0
Rola limfocytów Th17 w patogenezie raka jelita grubego
Szacuje się, że rak jelita grubego (RJG) zajmuje pierwsze miejsce wśród przyczyn zgonów na nowotwory złośliwe u mężczyzn i kobiet w UE. Każdego roku w Polsce odnotowuje się 15 254 nowych przypadków RJG oraz 10 501 przypa...
A game of survival: herpesvirus strategies of autophagy manipulation
Viruses are a very “clever” group of pathogens and well known for disrupting multiple processes in host cells. One of them is autophagy, a conserved mechanism that relies on degradation of intracellular structures in lys...
Biologiczna rola interleukiny 33 i znaczenie w patofizjologii układu sercowo-naczyniowego
Interleukina 33 (IL-33) należy do rodziny cytokin IL-1. Podlega ekspresji w wielu komórkach i tkankach, głównie w komórkach nabłonka i śródbłonka. Jest cytokiną pełniącą dwojakie funkcje. Może działać jako tradycyjna cyt...
Resistance of Pseudomonas aeruginosa to antibiotics
The main problem in the treatment of nosocomial infections is the increasing drug resistance of microorganisms that cause them, limiting the number of effective antibiotics. Pseudomonas aeruginosa bacilli are the cause o...
Znaczenie fosfofruktokinazy II (PFK-2)/fruktozo-2,6-bisfosfatazy (FBPazy-2) w przeprogramowaniu metabolicznym komórek nowotworowych
Utrzymanie dużej aktywności glikolitycznej w komórkach nowotworowych jest konieczne do zapewnienia odpowiedniego poziomu energii oraz składników budulcowych dla intensywnie proliferujących komórek. Na uwagę zasługuje to,...