The Influence of Endurance training on serum Levels of IL-17 in mice with breast cancer
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2013, Vol 7, Issue 7
Abstract
The purpose of this study was to investigate the influence of endurance training on IL-17 levels in tumor as well as on tumor volume in female bulb/C mice with breast cancer. To do so, 20 bulb/C mice (4-5 weeks old with mean body mass of 17 grams) were randomly put into two groups of 10: one as Resting Tumor-Exercise (RTE) group and the other as the Resting –Tumor-Resting (RTR) group. After inducing a tumor within the breast texture, the influence of endurance training was investigated on IL-17 levels as well as on tumor volume. The endurance training was applied for 6 weeks with intensity of 55- 70% VO2max. Levels of IL-17 were measured through ELISA method at the end of protocol. The obtained data were then analyzed through SPSS 20 using independent t-test, partial correlation coefficient as well as Pearson correlation with a significance threshold of P?0.05. Results of independent t-test showed that there is no significant difference between IL-17 levels in the RTR and RTE groups. The same test for the tumor volume, however, revealed that there is a significant difference (P=0.0001) between the tumor volume in two groups. Results of partial correlation coefficient and Pearson coefficient showed that there is no significant relationship between IL-17 textural levels and tumor volume among female bulb/C mice with breast cancer after a series of endurance training (P>0.05). Therefore, it seems that there are factors other than increased levels of interleukin 17 which plays different roles in decrease of tumor volume cancer index. Taking endurance training is, however, suggested as a non-risky adjuvant therapy in breast cancer.
Authors and Affiliations
Parisa ehsan| Exercise Physiology, Islamic Azad University, olum tahghighat Kerman, Iran. email: ehsan13781378@yahoo.com, abdolreza kazemi| Department of Physical Education, Valiasr University, Rafsanjan, Iran, Rasoul Eslami| Member of the Scientific Board, Allameh Taba Tabaei University, Tehran, Iran, Roohollah Ranjbar| Member of the Scientific Board , Shahid Chamran University , Ahwaz,Iran
Keywords
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