THE INFLUENCE OF PROPYLENE GLYCOL AND PEG 400 AS PLASTICIZER AGAINST PHYSICAL PROPERTIES PATCH OF ARECA CATECHU L. SEEDS EXTRACT
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 11
Abstract
Extract of Areca catechu L. seeds was formulated in patch preparation. Components that affect the physical properties of the patch are polymers and plasticizers. The polymer that used was a combination of HPMC-PVA. While Propylene Glycol and Poly Ethylene Glycol (PEG) 400 as a plasticizer. The research aim is to determine the influence of Propylene Glycol and PEG 400 as a plasticizer on physical properties of the patch. The evaluation includes weight uniformity, the percentage of water content, thickness, tensile strength and the percentage of elongation patch. The results showed that Propylene Glycol plasticizer can produce the patch with average weight 0,4546 g, the percentage of water content 8,6731%, thickness 0,1898 mm, tensile strength 0,15 Kgf/mm2 and the percentage of elongation 65,2222%. While plasticizer PEG 400 produces patch with average weight 0,5032 g, the percentage of water content 7,4234%, thickness 0,2123 mm, tensile strength 0,5370 Kgf/mm2 and the percentage of elongation 58,95%. The conclusion is that Propylene Glycol and PEG 400 as plasticizers affect the physical properties of the patch including uniformity of weight, thickness, and tensile strength, which PEG 400 is the best plasticizer in patch formulation of A. catechu L extract.
Authors and Affiliations
Rise Desnita
Keywords
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- EP ID EP639921
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