The inhibition of rat leukocytes apoptosis under the condition of experimental diabetes mellitus type 1 by [i]Galega officinalis[/i] L. extract
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2013, Vol 26, Issue 4
Abstract
The article contains the data of Galega officinalis extract (GOE) nonalkaloid-containing fraction influence on the structural and functional state of leukocytes under the condition of experimental diabetes mellitus type 1 (EDM). Immunohistochemical method has shown the quantitative redistribution of leukocytes containing proapoptotic protein p53 and PARylated [poly(ADP-ribosyl) ated] proteins under EDM conditions and admission of the tested extract. GOE administration to animals with EDM leads to the reduction in the number of cells with positive and strongly positive reaction to the p53 protein and PARylated proteins content, indicating its depressing effect on apoptosis of immune cells.
Authors and Affiliations
Mariia Khokhla, Galyna Kleveta, Marjana Lupak, Yaroslav Chajka, Natalia Sybirna
Keywords
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