The meaning of sputum eosinophil in childhood asthma and its current application
Journal Title: JOURNAL OF FUNCTIONAL VENTILATION AND PULMONOLOGY - Year 2018, Vol 9, Issue 26
Abstract
Eosinophil infiltration plays an important role in the pathogenesis of asthma. It is important for a health care provider to determine which subtype of asthma a person might have, because there are now new therapies that target specific subgroups of asthma, like eosinophilic asthma. The term “eosinophilic asthma” describes a subphenotype of asthma that is characterised by elevated levels of eosinophils in bronchial biopsies or sputum despite chronic and correct use of adequate doses of inhaled corticosteroids (ICS). Traditionally, airway biopsies or bronchoalveolar lavage through bronchoscopy is considered as the gold standard for assessing airway inflammation but the invasiveness of these methods limits their use in clinical practice. Biomarkers for type 2 (TH2) inflammation, including FENO (fractional exhaled nitric oxide) levels and blood/sputum eosinophilia and serum periostin levels, have helped to identify a type 2 molecular phenotype of asthma. Sputum induction and differential cell count, unfortunately, are available only in a limited number of specialized centers. Although numerous studies in adults have shown induced sputum analysis to be a useful and safe tool in the evaluation of asthma, very few studies have evaluated this tool in children. In Vietnam, hardly no clinical setting has applied sputum eosinophil in monitoring asthma because of strict requirements of the method. Thus, here is really avoid space for Vietnamese researchers, especially pulmonologists, that they need to compensate it in the future.
Authors and Affiliations
HO-LY-MINH Tien
Keywords
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- EP ID EP388661
- DOI 10.12699/jfvpulm.9.26.2018.3
- Views 62
- Downloads 0
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