The Monocyte/HDL Cholesterol Ratio in Obstructive Sleep Apnea Syndrome
Journal Title: Meandros Medical and Dental Journal - Year 2019, Vol 20, Issue 3
Abstract
Objective: Obstructive Sleep Apnea syndrome (OSAS) is the most common condition among sleep-related respiratory disorders. The etiology is not clear. However, systemic and local inflammation in the respiratory tract of the patients has been acknowledged. Monocytes and macrophages play the critical role in the inflammation process. These cells participate in the release of the proinflammatory cytokines in inflammation sites. High-density lipoprotein (HDL) cholesterol is a molecule with an anti-inflammatory effect. Monocyte/HDL cholesterol ratio (MHR) is an inflammation marker being used recently. In our study, we aimed to compare inflammation marker levels between patients diagnosed with OSAS with subsequent polysomnography and the non-OSAS group, determine the relationship between the severity of OSAS and MHR and, investigate the utility of the MHR for diagnosing OSAS. Materials and Methods: The data from the patients’ files who had polysomnography due to OSAS symptoms in our unit between July 2017 and December 2017 have been retrospectively analyzed, and polysomnography results were recorded. Demographic data and the results of biochemistry and complete blood count panels of patients with OSAS and who were not also were recorded. Results: Out of 147 patients who underwent polysomnography in the period identified, 104 were diagnosed with OSAS. Monocyte count and MHR values were significantly high (p<0.0001 in both) and HDL levels were significantly low (p=0.03) in OSAS group. There was also a moderately significant positive correlation between apnea-hypopnea index (AHI) and MHR (p<0.0001, r=0.411). Conclusion: MHR may be a useful tool for diagnosing OSAS. Because of the positive correlation between MHR and AHI which represents the severity of the disease, MHR may be used for the classification of OSAS.
Authors and Affiliations
Murat Acat, Onur Yazıcı
Keywords
Related Articles
- EP ID EP684879
- DOI 10.4274/meandros.galenos.2018.63935
- Views 143
- Downloads 0
A Comparison of Chewing Movements of Individuals with Normal Occlusion by the Patients with Orthodontic Abnormalities During Treatment Progress
Objective: Comparison of chewing movements of individuals with normal occlusion and those with orthodontic anomalies under treatment. Materials and Methods: This is a prospective clinical study carried out on a total of...
Disagreements in the Approach to the N0 Neck and their Causes in Head and Neck Cancers
There are numerous controversial issues in the management of patients with N0 neck. Whether the diagnosis of N0 neck should be made based on the physical examination or imaging methods is contradictory in the first place...
Investigating the Effect of Rosuvastatin, Paracetamol and Co-administration of Rosuvastatin and Paracetamol on Ocular Tissue
Objective: Statins and Paracetamol are two drugs that have a high prescription rate all over the world. Possible side effects can easily be augmented because they use the same cytochrome oxidase enzymes in liver. This st...
Retroperitoneal Tunneled Hemodialysis Catheter in Inferior Vena Cava: A Report of Three Cases
Finding an appropriate vascular access is difficult in long term hemodialysis patients for emergency hemodialysis. The aim of this study was to present tunneled hemodialysis catheter placement to inferior vena cava throu...
Non-surgical Root Canal Retreatment: A Retrospective Outcome Study
Objective: When the prognosis of a root canal treated (RCT) teeth is poor, retreatment (RT) of the former RCT is indicated. The aim of this study was to assess the long-term success rate of nonsurgical retreatment for fi...