The neuroprotective effects of garlic, ginger, and sodium selenite on mercuric chloride toxicity in mice
Journal Title: Journal of Multidisciplinary Sciences - Year 2019, Vol 1, Issue 2
Abstract
Mounting evidence suggests that mercuric chloride (HgCl2) exposure associated with a broad spectrum of toxicological signs, including neurobehavioral and neurochemical abnormalities. It was owing to antioxidant, anti-apoptotic, and anti-inflammatory properties of garlic, ginger, and sodium selenite (Na2SeO3), providing stable rationality to block the multifaceted neurotoxicologically pathways of HgCl2. Therefore, the present study was carried out to investigate the neuroprotective potential of these nutritional strategies against the HgCl2-induced neurotoxic mice model. 75 albino mice were randomly and equally divided into 5 groups, and 15 mice each to achieve this objective. The group 1 was kept as a control, and group 2 was administered HgCl2 at a dose 4 mg/kg BW. The groups 3, 4, and 5 were administered HgCl2 in association with garlic and ginger oils and Na2SeO3 at doses of 63, 50, and 0.1 mg/kg BW, respectively. HgCl2 and the treatments were supplemented orally through the stomach tube 3 times weekly for 6 weeks. Half of the mice were decapitated from each group after 4 weeks, and the others decapitated at the end of the experimental period. HgCl2 caused neurological deterioration as indicated by depletion of catalase activity, and induction of apoptosis and histopathological afflictions. However, chronic treatment with the three natural therapeutically approaches exerted neuroprotective effects by ameliorating the above-mentioned disturbances.
Authors and Affiliations
Sohair Mohamed Mahmoud Ragab, Emad Abel Aziz Ahmed, Hanaa Gamal Ahmed, Mokhtar Mostafa Mohamed Taha, Mahmoud Abdelzaher Abdel-Samii
Keywords
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- EP ID EP683701
- DOI https://doi.org/10.33888/jms.2019.128
- Views 204
- Downloads 0
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