The physiology of vitamin D and its involvement in cardiovascular diseases
Journal Title: Central Asian Journal of Medical and Pharmaceutical Sciences Innovation - Year 2022, Vol 2, Issue 4
Abstract
Cardiovascular diseases (CVD) is a leading reason of global mortality. The most common causes of CVD-related deaths are ischemic heart disease, congestive heart failure, and stroke. Cardiac ischemia is correlated with coronary artery stenosis, which disrupts blood flow to the muscle of heart, also recognized as coronary artery disease. A stroke is also caused by a sudden blockage of blood flow to the brain or a rupture of blood vessels, both of which block blood flow to the brain tissue and deprive the brain of glucose and oxygen. Cardiovascular diseases can be affected by ethnicity, gender, lifestyle, genetic factors, and so on. Vitamin D, now known as a neurosteroid, have a main role in the body's physiological activities. Vitamin D is a fat-soluble vitamin that could be synthesized in the skin and act as a hormone. Vitamin D deficiency increases the susceptibility to vascular disease and ischemic stroke in people. Vitamin D may have a main role in cardiovascular disease by interfering with various mechanisms such as inflammation, thrombosis, renin-angiotensin system, etc. The aim of this study was to describe the important cardiovascular diseases and the physiology of vitamin D and its role in cardiovascular diseases.
Authors and Affiliations
Betul Ozdemir; Alamgir Khan; Rzgar Farooq Rashid
Keywords
Related Articles
- EP ID EP714395
- DOI 10.22034/CAJMPSI.2022.04.02
- Views 64
- Downloads 0
The cellular and molecular role of exosomes in the pathophysiology of cancer
Exosomes are small extracellular particles enclosed in two lipid layers with the endosomal origin that contain nucleic acids, proteins, and lipids, and are secreted by most cell types. They can transmit their contents fo...
Influence of rs1800172 common gene variation on the structure and function of potassium voltage-gated channel subfamily Q member 1
The proper functioning of ion channels is essential for cell survival. One of the important ion channels is potassium voltage-gated channel subfamily Q member 1 (KCNQ), which consists of five genes whose main gene is KCN...
Human protamine 1 gene structure and function affected by rs35576928 mutation: a bioinformatics analysis
Human sperm contain most type 1 and type 2 protamines (PRM1) and (PRM2), protamines, which have about equal proportions in normal sperm. Protamines can infertile if they change structure or function. Nucleotide polymorph...
Association analysis of rs1800470 (T869C) variation in TGFB1 gene with the risk of ischemic stroke in Asian population
Stroke is a disease that can lead to death or long-term disability. Genetic polymorphisms in key genes can alter the risk of developing the disease. The aim of this study was to investigate the association of rs1800470 p...
Cellular and molecular mechanisms involved in age-related hearing loss with focusing on oxidative stress
Age-related hearing loss (ARHL) is a type of bilateral hearing loss that progresses from low frequencies to high frequencies with age. This disorder is classified as a multifactorial disease. Factors involved in ARHL pat...