The potential effects of non-renal factors, glucocorticoid treatment and hematological malignancies, on serum cystatin C level
Journal Title: Trends in Pharmaceutical Sciences - Year 2017, Vol 3, Issue 1
Abstract
Cystatin C as a novel marker of kidney function may have some drawbacks in clinical practice. The aim of the present study was to assess the impact of glucocorticoid therapy and hematological malignancies on serum cystatin C level in patients receiving amphotericin B. Forty five adult patients with no history of acute or chronic kidney injury planned to receive conventional amphotericin B for an anticipated duration of at least 1 week for any indication were included. At the time of amphotericin B treatment, serum cystatin C as well as creatinine levels, were measured at days 0, 7, and 14. There was no statistically significant association between hematological malignancies and elevated serum Cys C at days 0 (P=0.0705), 7 (P=0.679), and 14 (P=1). The mean±SD serum Cys C levels at the three time points were comparable between patients receiving glucocorticoids and those not having been given glucocorticoids. Our findings suggested that glucocorticoid treatment and hematological malignancies appear to have no significant effect on the serum cystatin C level in patients recieving amphotericin B treatment.
Authors and Affiliations
Iman Karimzadeh, Hossein Khalili
Keywords
Related Articles
- EP ID EP320990
- DOI -
- Views 133
- Downloads 0
N-Phenyl Ureidobenzenesulfonate derivatives as novel anticancer agents: QSAR and Molecular docking studies
DNA double strand-breaks (DSBs) are the most deleterious lesions that can affect the genome of living beings and are lethal if not quickly and properly repaired. Recently, N-phenyl ureidobenzenesulfonates (PUB-SOs) as tu...
Protective Effect of Glycine and Tri-Methyl Glycine (Betaine) Against Heavy Metals-Induced Oxidative Stress in Liver-Derived Post-Nuclear Supernatant (PNS)
Heavy metals are environmental pollutants, which pose toxicity toward biological systems. Most organs are susceptible to heavy metals-induced toxicity. Hence, finding protective agents against heavy metals-induced toxici...
Analysis of six populations of Commiphora myrrha (Nees) Engl. oleo-gum resin
True myrrh is produced by wounding the plant Commiphora myrrha (Nees) Engl. A number of oleo-gum-resins are produced from various species of Commiphora. Many of these gummy substances resemble myrrh; and sometimes are us...
Comparison of docking procedures and its efficiency for Betasecretase, Aromatase and Pyruvate dehydrogenase kinase inhibitors
Proper docking protocols were presented for three known enzyme structures, human betasecretase (BACE1), Aromatase and pyruvate dehydogenase kinase (PDHK) using Autodock4.2 and Vina softwares. The validity of docking prot...
The Hepatoprotective Role of Thiol Reductants against Mitoxantrone-Induced Liver Injury
Mitoxantrone is an anthracycline antibiotic highly effective against various human cancers. Hepatotoxicity is associated with mitoxantrone administration. On the other hand, there is no effective therapeutic option again...