The rational choice of drugs for the dyspepsia treatment in an outpatient clinic
Journal Title: Сучасна гастроентерологія - Year 2018, Vol 0, Issue 5
Abstract
Objective — to conduct a comparative evaluation of the clinical efficacy of pantoprazole, aluminium phosphate gel and drotaverine in the treatment of patients with dyspepsia. Materials and methods. The open comparative study involved 97 patients with dyspepsia, from them 54 women (55.67 %), 43 men (44.33 %). The age of patients ranged from 18 to 32 years (mean 26.8 ± 7.6 years). Patients were randomly divided into three groups; patients of the 1st group (n = 34) took pantoprazole (Zolopent®, Kusum Farm, Ukraine). In the 2nd group (n = 31), oral aluminium phosphate gel was used for treatment, drotaverine in the 3rd group (n = 32), the treatment course lasted 14 days. To assess therapeutic efficacy, a 5-point scale was used; patient satisfaction with therapy was judged on the basis of a 10-point visual analogue scale. Results. The dyspeptic manifestations were eliminated in the best way in the 1st group. In this group, 94.12 % of patients fully completed the treatment, in the 2nd and 3rd groups the portion was 83.87 and 75 %, respectively. The highest values of satisfaction with therapy were demonstrated in the group of pantoprazole, 8.52 ± 1.14 (n = 32); the significant differences were obtained from the ratings of patients in the 2nd and 3rd groups, respectively, 5.71 ± 0.68, p < 0, 05 (n = 26) and 4.33 ± 0.88 p < 0.01 (n = 24). Conclusions. A comparative evaluation of the clinical efficacy of pantoprazole, aluminium phosphate gel and drotaverine in the treatment of patients with dyspepsia over the course of 2 weeks has shown that the best result has been achieved in the majority of patients, administered pantoprazole in a daily dose of 40 mg. Patients of this group had have the highest therapy satisfaction rate.
Authors and Affiliations
M. B. Shcherbynina, V. M. Hladun, T. M. Shevchenko, M. V. Lusta
Keywords
Related Articles
- EP ID EP418344
- DOI 10.30978/MG-2018-5-67
- Views 130
- Downloads 0
V Maastricht consensus: the personified approach to the eradication therapy with account of the regional peculiarities of Ukraine
The key provisions of the V Maastricht Consensus on the diagnosis and treatment of Helicobacter pylori infection have been considered. The analysis has been performed for the main results of eradication therapy for the l...
The new possibilities for the treatment of patients with chronic constipation
Objective — to analyze the efficacy of using the herbal drug EasyDo in patients with chronic constipation. Materials and methods. The observations involved 40 patients with chronic constipation, aged 18 to 65 years, who...
Intensity of oxidative and nitrosative stress in patients with nonalcoholic steatohepatitis and comorbid chronic kindney disease
Objective — to establish intensity of the oxidative and nitrosative stress at the comorbid course of nonalcoholic steatohepatitis (NASH) and chronic kidney disease (CKD) of the 1st and 2nd stages. Materials and methods....
The relationship between the body mass index and the Firmicutes/Bacteroidetes ratio in the intestinal microbioume of the adult population of Ukraine
Objective — to investigate the difference in the composition of the main intestinal microbiota types in the adult population of Ukraine and their relationship with the body mass index (BMI). Materials and methods. Invest...
Nutrigenetic characteristics of patients with nonalcoholic liver disease combined with metabolic syndrome
Objective — to detect possible association of polymorphisms of the Pro12Ala of PPARG2 gene (rs1801282) and ADRB3 gene (rs4994) with a degree of fatty liver and metabolic disorders in patients with NAFLD. Materials and m...