THE RELATIONSHIP BETWEEN ARTERIAL STIFFNESS AND DISEASE SEVERITY IN PATIENTS WHO HAVE HAD COVID-19
Journal Title: Kocatepe Medical Journal - Year 2024, Vol 25, Issue 3
Abstract
OBJECTIVE: Endothelial dysfunction plays an important role in the pathogenesis of target organ damage associated with COVID-19. In patients with COVID-19, cardiovascular (CV) complications due to strong inflammatory damage are more frequently observed in intensive care units patients compared to outpatients. In this study, we aimed to investigate whether the relationship between the severity of COVID-19 infection and arterial stiffness (AS) could be a predictor of future CV events, in patients who had COVID-19 infection. MATERIAL AND METHODS: Patients were divided into two groups as those admitted to the intensive care unit (severe group) and outpatients (mild group), based on the COVID-19 severity. Patients without COVID-19 were included in the study as a control group. The biochemical parameters of the patients were obtained retrospectively from the hospital database. AS and echocardiographic measurements for all groups were performed within the first month after COVID-19 infection. RESULTS: A total of 84 patients, 27 of whom were in the control, 32 in the mild disease and 25 in the severe disease groups, were included in the study. The mean age of the study population was 48.68±12.9 years, and 58 (69%) were male. The mean pulse wave velocity values obtained in AS measurements were 8.02 m/s in the control group, 8.07 m/s in the mild disease group and 8.75 m/s in the severe disease group. AS value of patients with severe disease who were treated in intensive care unit was significantly higher compared to controls and those with mild disease (p=0.007, p=0.008, respectively). However, there was no statistically significant difference in AS values between the patients with mild disease and control group (p=0.681). CONCLUSIONS: In our study, we found higher arterial stiffness values in patients who had severe COVID-19 infection. This result may be explained by endothelial damage secondary to exaggerated and uncontrolled inflammation. Therefore, high pulse wave velocity values in such patients may be used as a predictor of future cardiovascular events.
Authors and Affiliations
Lütfullah CANDAN, Merih KUTLU, Mürsel ŞAHİN
Keywords
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- EP ID EP740662
- DOI https://doi.org/10.18229/kocatepetip.1390586
- Views 22
- Downloads 0
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