The Relationship Between Endothelial Functions and HDL/LDL Ratios in Patients with Coronary Artery Disease
Journal Title: E Journal of Cardiovascular Medicine - Year 2020, Vol 8, Issue 4
Abstract
Objectives: Endothelial dysfunction plays an important role in the initial stage of atherosclerosis, the growth of atherosclerotic plaque and the development of thrombogenic events. Low-density lipoprotein (LDL) cholesterol levels are associated with the risk of cardiovascular disease. It also inhibits endothelium-dependent vasodilation by disrupting the activity of nitric oxide (NO) synthase and causes endothelial dysfunction. It has been shown that high-density lipoprotein (HDL) cholesterol increases the production of NO and endothelial NO synthase that causes vascular dilatation directly or indirectly, and also supports endothelial cell migration and proliferation through different mechanisms. In our study, we aimed to investigate the relationship between HDL/LDL ratios and endothelial functions in patients with coronary artery disease (CAD) documented through coronary angiography (CAG). Materials and Methods: Fifty-seven patients with CAD documented through CAG were included in the study. Endothelial functions were evaluated with the flow mediated vasodilation (FMD) test, which is the most commonly used non-invasive method for endothelial function assessment. In statistical analysis, the change in arterial diameter was examined by the paired sample t-test. Results: The average age of 57 patients included in the study was 61.1±10.1 years and 70% of these patients were male and 30% were female. The mean body mass index was 27.8±5.7 kg/m2 and 57.9% of the patients were NYHA class I. In the FMD test, the mean radial artery percentage diameter change was found to be 12.61% (±3.62). The average HDL/LDL ratio of the patients included in the study was 0.53 (±0.26), and the median value was 0.42 (minimum 0.27 - maximum 1.50). There was a weak positive correlation between HDL/LDL ratios and FMD percentage change (r =+0.379, p=0.04). Conclusion: As HDL/LDL ratios increase in patients with CAD, the percentage change of flow-mediated dilatation, which is an indicator of endothelial functions, also increases.
Authors and Affiliations
Mehmet Kış, Elton Soydan, Mustafa Akın
Keywords
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- EP ID EP691467
- DOI 10.32596/ejcm.galenos.2020.10.055
- Views 113
- Downloads 0
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