The relationship between severity of mitral valvular stenosis and the level of serum brain natriuretic peptide
Journal Title: Dicle Tıp Dergisi - Year 2011, Vol 38, Issue 4
Abstract
Objectives: Although there have been a considerable number of reports about BNP levels in patients with mitral stenosis (MS), the relationship between the brain natriuretic peptid (BNP) level and the severity of MS is not investigated extensively in patients with sinus rhythm. In this study we aimed to evaluate plasma BNP levels in patients with MS and to determine the relation of BNP levels with the anatomic and physiological severity of MS. Materials and methods: Ninety six patients with isolated rheumatic MS and 40 healthy control subjects (group 1) constituted the study population. The patients with MS were classified as those with mild MS (45 patients, group 2), moderate MS (31 patients, group 3) and severe MS (20 patients, group 4). All subjects underwent a detailed echocardiography and venous blood was drawn for BNP levels. Results: Patients with MS had significantly higher BNP levels than control subjects. In addition, the analysis with respect of the severity of MS showed that BNP levels increased significantly from group 1 through to group 4. In correlation analysis, while there was a good correlation between BNP levels with planimetric mitral valve area and pulmonary artery pressure, there was moderate correlation between BNP levels with left atrial diameter, mean and maximum gradients. Conclusion: We demonstrated that plasma BNP levels were correlated with echocardiographic parameters showing the severity of the MS. Natriuretic peptides might be useful in the clinical and echocardiographic evaluation of MS patients as an indicator of disease severity.
Authors and Affiliations
Emine Bilen, Mustafa Kurt, İbrahim Tanboğa, Hüseyin Ayhan, Mehmet Karakaş, Hasan Kaya, Engin Bozkurt
Keywords
Related Articles
- EP ID EP155671
- DOI -
- Views 150
- Downloads 0
Evaluation of intraocular pressure and retinal nerve fiber layer thickness in patients with Helicobacter pylori
Objective: High prevalence of Helicobacter pylori (HP) in the glaucoma patients was shown in recent studies. In our prospective study we aimed to compare the intraocular pressure (IOP) and the retinal nerve fiber laye...
Our results of mini open approach in patients with carpal tunnel syndrome
Objective: In this study, we aimed to evaluate the results of patients underwent surgical release with mini open surgical method due to Carpal tunnel syndrome (CTS) and the surgical technique. Methods: 50 wrists of the...
İnfektif endokarditin klinik sonuçları üzerine hematolojik ve biyokimyasal parametrelerin etkisi
Amaç: Çalışmamızda İnfektif endokarditli (İE) hastalarda hematolojik parametrelerdeki değişiklikleri ve bu değişikliklerin komplikasyon ve mortalite oranları ile ilişkisini araştırmayı amaçladık. Gereç ve yöntem: Dicle...
Reliability and validity in medical research
Scientists commonly refer to study instruments during medical research. In fact, the reliability and validity issues go beyond psychometric studies and can be linked with any kind measurements. In this study we aimed...
Çocuklarda başlangıç perkütan nefrolitotomi deneyimimiz
Amaç: Mart 2012 ve Kasım 2013 tarihleri arasında Dicle Üniversitesi Tıp Fakültesi Çocuk Cerrahisi Kliniğinde çocuk yaş grubunda yapılan perkütan nefrolitotomi (PNL) deneyimlerimizi sunmaktır. Yöntemler: On üç böbrek...