The role of fungal sensitization in the pathogenesis of asthma and alergic diseases (review)
Journal Title: Астма и Аллергия - Year 2018, Vol 1, Issue 4
Abstract
The prevalence of fung а l sensitization is 3–10% in the general population of Europe . However , its role is not determined definitely : whether micromycetes are one of the etiological sensitization factors , or it only aggravates the course of asthma and allergic diseases , or reflects the state of cross - sensitization in patients , as a casual association . Fungal allergy can manifest as the form of asthma , rhinitis , conjunctivitis , urti - caria , atopic dermatitis . It is well - documented studies on the importance of Alternaria , Cladosporium , Penicillium , Aspergillus , and Malassezia fungi in the development or deterioration of allergic diseases . Micromycetes Curvularia , Bipolaris , Drechslera , Exserohilum and others are also involved in the development of allergic diseases . 111 fungal allergens are presented in the international nomenclature of allergens . It has been found out that severe persistent asthma in adults is often associated with fung а l sensitization . The powerful factors affect the spectrum of fun - gal allergy . There are climate , indoor humidity , especially for children . The presence of cross - reacting allergen causes additional difficulties in the determination of fungal sensitization . It based on the presence of common B - cell antigenic determinants in homologous proteins . The main difficulties of the study of fungal allergy are related to the problems of standardization of methods , preparations and reagents , which can lead to different research results .
Authors and Affiliations
O. M. Rekalova, L. V. Petrenko
Keywords
Related Articles
- EP ID EP462847
- DOI 10.31655/2307-3373-2018-4-37-45
- Views 169
- Downloads 0
Usage of medical thermography to evaluate the results of skin prick testing of patients with allergic rhinitis
Метою дослідження було вивчення аспектів використання медичної термографії для оцінки результатів шкірного тестування розчинами алергенів у пацієнтів з алергічним ринітом у порівнянні з імуноблотингом. Матеріали та...
Allergic bronchopulmonary aspergillosis: XXI century. A modern view on the problem
Aspergillus organisms are widely ubiquitous in the environment and can cause a great number of pathological syndromes mainly in immunocom promised patients . However , aspergillosis lesion may occur not only in patie...
FEATURES OF CHANGES IN THE INDICATORS OF T-CELL IMMUNITY IN PATIENTS WITH DIFFERENT CONTROLLING OF BRONCHIAL ASTHMA AND THEIR PROGNOSTIC VALUE
The aim: to determine the prognostic assessment of T-cell immunity changes which are based on the study of their features in bronchial asthma (BA) patients with its different controllability. Materials and methods. 133...
METABOLIC PHENOTYPES OF COPD: PECULIARITIES OF PATIENT MANAGEMENT (review of literature, own research results)
CImportance of the determination and correction of metabolic changes in patients with chronic obstructive pulmonary disease (COPD) increases with each passing year. Nutritional disorders, sarcopenia, obesit...
MODERN APPROACHES TO THE INHALATION THERAPY IN PULMONARY BRONCHOOBSTRUCTIVE PATHOLOGY
Introduction. Problems of the inhalation therapy of obstructive lung diseases are relevant and were discussed actively at the congress of European Respiratory Society. In this article we review one of the sessions devote...