The role of fungal sensitization in the pathogenesis of asthma and alergic diseases (review)
Journal Title: Астма и Аллергия - Year 2018, Vol 1, Issue 4
Abstract
The prevalence of fung а l sensitization is 3–10% in the general population of Europe . However , its role is not determined definitely : whether micromycetes are one of the etiological sensitization factors , or it only aggravates the course of asthma and allergic diseases , or reflects the state of cross - sensitization in patients , as a casual association . Fungal allergy can manifest as the form of asthma , rhinitis , conjunctivitis , urti - caria , atopic dermatitis . It is well - documented studies on the importance of Alternaria , Cladosporium , Penicillium , Aspergillus , and Malassezia fungi in the development or deterioration of allergic diseases . Micromycetes Curvularia , Bipolaris , Drechslera , Exserohilum and others are also involved in the development of allergic diseases . 111 fungal allergens are presented in the international nomenclature of allergens . It has been found out that severe persistent asthma in adults is often associated with fung а l sensitization . The powerful factors affect the spectrum of fun - gal allergy . There are climate , indoor humidity , especially for children . The presence of cross - reacting allergen causes additional difficulties in the determination of fungal sensitization . It based on the presence of common B - cell antigenic determinants in homologous proteins . The main difficulties of the study of fungal allergy are related to the problems of standardization of methods , preparations and reagents , which can lead to different research results .
Authors and Affiliations
O. M. Rekalova, L. V. Petrenko
Keywords
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- EP ID EP462847
- DOI 10.31655/2307-3373-2018-4-37-45
- Views 138
- Downloads 0
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